Colorectal cancer subtypes: Translation to routine clinical pathology

Highlights • Consensus Molecular Subtypes of CRC utilize mRNA profiling. • mRNA profiling is not easily translated to the clinical setting. • Phenotypic features of CRC are the most prognostic and easily translated to clinic. • Phenotypic subtyping could be the first step towards precision medicine...

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Bibliographic Details
Published in:Cancer treatment reviews 2017-06, Vol.57, p.1-7
Main Authors: Roseweir, Antonia K, McMillan, Donald C, Horgan, Paul G, Edwards, Joanne
Format: Article
Language:English
Subjects:
Colorectal cancer
Colorectal Neoplasms - classification
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Genomic
Hematology, Oncology and Palliative Medicine
Humans
Molecular subtypes
Oligonucleotide Array Sequence Analysis - methods
Phenotypic
RNA, Messenger - genetics
Transcriptome
Translational
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Summary:Highlights • Consensus Molecular Subtypes of CRC utilize mRNA profiling. • mRNA profiling is not easily translated to the clinical setting. • Phenotypic features of CRC are the most prognostic and easily translated to clinic. • Phenotypic subtyping could be the first step towards precision medicine for CRC.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2017.04.006