Systemic inflammation and alterations to cerebral blood flow in obstructive sleep apnea

Summary Systemic inflammation and alterations to regional cerebral blood flow (CBF) have been reported previously in obstructive sleep apnea (OSA). This study utilized arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI) to evaluate CBF in OSA patients and determine its relations...

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Bibliographic Details
Published in:Journal of sleep research 2017-12, Vol.26 (6), p.789-798
Main Authors: Chen, Hsiu‐Ling, Lin, Hsin‐Ching, Lu, Cheng‐Hsien, Chen, Pei‐Chin, Huang, Chih‐Cheng, Chou, Kun‐Hsien, Su, Mao‐Chang, Friedman, Michael, Chen, Yi‐Wen, Lin, Wei‐Che
Format: Article
Language:English
Subjects:
Adult
Apoptosis
Blood Pressure
cerebral perfusion
Cerebrovascular Circulation
Female
Hemodynamics
Humans
Inflammation - complications
intermittent hypoxia
Leukocytes - pathology
magnetic resonance imaging
Male
oxidative stress
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - physiopathology
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Summary:Summary Systemic inflammation and alterations to regional cerebral blood flow (CBF) have been reported previously in obstructive sleep apnea (OSA). This study utilized arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI) to evaluate CBF in OSA patients and determine its relationship with systemic inflammation. Twenty male patients with moderate and severe OSA [apnea–hypopnea index (AHI) >15] and 16 healthy male volunteers (AHI
ISSN:0962-1105
1365-2869
DOI:10.1111/jsr.12553