Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo

Highlights • Insulin and glargine had similar effects on neural functions in vitro and in vivo. • Detemir was less effective than insulin in neural cells in the presence of albumin. • Insulin and glargine improved brain functions more potently than detemir in mice. • Albumin may compromise the benef...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-07, Vol.129, p.62-72
Main Authors: Tsuneki, Hiroshi, Yoshida, Hitomi, Endo, Kosuke, Mori, Norihiko, Hosoh, Shuji, Tsuda, Masaaki, Wada, Tsutomu, Sasaoka, Toshiyasu
Format: Article
Language:English
Subjects:
Animals
Brain
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Dementia
Depression
Endocrinology & Metabolism
Female
Humans
Hypoglycemic Agents - pharmacology
Insulin analog
Insulin Detemir - pharmacology
Insulin Glargine - pharmacology
Insulin, Long-Acting - pharmacology
Male
Mice
Mice, Inbred C57BL
Neuron
Neurons - drug effects
Phosphorylation
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-akt - metabolism
Rats
Rats, Sprague-Dawley
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Summary:Highlights • Insulin and glargine had similar effects on neural functions in vitro and in vivo. • Detemir was less effective than insulin in neural cells in the presence of albumin. • Insulin and glargine improved brain functions more potently than detemir in mice. • Albumin may compromise the beneficial effects of acylated insulin analog in brain.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.03.032