Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer

Abstract The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy v...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2017-05, Vol.120, p.25-31
Main Authors: Zhang, Li-jian, Chen, Bin, Zhang, Jun-jie, Li, Jian, Yang, Qingjing, Zhong, Qi-sheng, Zhan, Song, Liu, Huwei, Cai, Chun
Format: Article
Language:English
Subjects:
Adult
Advanced Basic Science
Aged
Arachidonic Acid - blood
Biomarkers - blood
Chromatography, High Pressure Liquid
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - diagnosis
Endocrinology & Metabolism
Fatty Acids, Unsaturated - blood
Female
Humans
Hydroxyeicosatetraenoic Acids - blood
Linoleic Acid - blood
Lipidomic
Male
Mass spectrometry
Middle Aged
Tandem Mass Spectrometry
Ultra-high performance liquid chromatography
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Summary:Abstract The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy volunteers, and then we tested the change of serum PUFA metabolites in both of them by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Of the 158 PUFA and their metabolites, we found that abnormal change of 2, 3-dinor-8-iso-PGF2α, 19-HETE and 12-keto-LTB4 from arachidonic acid were observed in colorectal cancer patients. Meanwhile, 9-HODE and 13-HODE from linoleic acid were significant lower in colorectal cancer patients. Our data suggested that some PUFA metabolites might be used as a potential biomarker of colorectal cancer, which might provide assistance in clinical diagnosis and treatment.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2017.04.003