Severe hypertriglyceridemia : Diagnostics and new treatment principles

Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For...

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Bibliographic Details
Published in:Der Internist (Berlin) 2017-08, Vol.58 (8), p.866-876
Main Authors: Kassner, U, Dippel, M, Steinhagen-Thiessen, E
Format: Article
Language:ger
Subjects:
Acute Disease
Cardiovascular Diseases - etiology
Germany
Humans
Hypertriglyceridemia - diagnosis
Hypertriglyceridemia - genetics
Hypertriglyceridemia - therapy
Lipoprotein Lipase - physiology
Pancreatitis - etiology
Risk Factors
Triglycerides - blood
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Summary:Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For diagnosis, secondary factors have to be excluded and treated before further genetic tests are considered. Typical symptoms in almost all patients are recurrent, sometimes severe abdominal pain attacks, which can result in acute pancreatitis, the most important, sometimes life-threatening complication. To minimize the risk of severe pancreatitis, the aim is to maintain the plasma TG concentration
ISSN:1432-1289
DOI:10.1007/s00108-017-0234-z