Chitosan-co-Hyaluronic acid porous cryogels and their application in tissue engineering

[Display omitted] In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid...

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Bibliographic Details
Published in:International journal of biological macromolecules 2017-10, Vol.103, p.366-378
Main Authors: Kutlusoy, Tuğçe, Oktay, Burcu, Apohan, Nilhan Kayaman, Süleymanoğlu, Mediha, Kuruca, Serap Erdem
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Cell Adhesion - drug effects
Cell Proliferation - drug effects
Chitosan
Chitosan - chemistry
Cryogel
Cryogels - chemistry
Hyaluronic acid
Hyaluronic Acid - chemistry
Mechanical Phenomena
Mice
MTT
Porosity
Temperature
Tissue Engineering
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Summary:[Display omitted] In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid (0, 10, 20, 30 and 50wt% hyaluronic acid) was prepared. Morphological studies showed that the macroporous cryogels have been developed with 90–95% porosity. Particularly, the mechanical and biomaterial property of pure chitosan was improved by making copolymer with hyaluronic acid in different concentration. The MTT cell viability results demonstrated that the cryogels have no significant cytotoxicity effect on 3T3 fibroblast and SAOS-2 cells.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2017.05.067