Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model

Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydop...

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Bibliographic Details
Published in:Neuroscience 2017-07, Vol.356, p.176-181
Main Authors: Dati, L.M, Ulrich, H, Real, C.C, Feng, Z.P, Sun, H.S, Britto, L.R
Format: Article
Language:English
Subjects:
Animals
carvacrol
Disease Models, Animal
dopamine
Male
Mice, Inbred C57BL
Monoterpenes - pharmacology
Neurology
Neurons - drug effects
Neurons - metabolism
neuroprotection
Neuroprotection - drug effects
Neuroprotective Agents - pharmacology
Parkinson Disease - drug therapy
Substantia Nigra - drug effects
TRP channels
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Summary:Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydopamine was reduced by carvacrol.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.05.013