Redox signaling in remote ischemic preconditioning-induced cardioprotection: Evidences and mechanisms

Reactive oxygen species are the reactive molecules that are derived from molecular oxygen and play an important role as redox signaling molecules to confer cardioprotection. Various scientists have demonstrated the key role of redox signaling in cardioprotection by showing a transient increase in th...

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Bibliographic Details
Published in:European journal of pharmacology 2017-08, Vol.809, p.151-155
Main Authors: singh, Lovedeep, Randhawa, Puneet Kaur, Singh, Nirmal, Jaggi, Amteshwar Singh
Format: Article
Language:English
Subjects:
Animals
Antioxidant
Coronary Vessels - physiology
Coronary Vessels - physiopathology
Heart
Heat shock proteins
Humans
Ischemic Preconditioning
Myocardium - cytology
Myocardium - metabolism
Myocardium - pathology
Oxidation-Reduction
Reactive Oxygen Species - metabolism
Redox signaling
Remote preconditioning
Signal Transduction
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Summary:Reactive oxygen species are the reactive molecules that are derived from molecular oxygen and play an important role as redox signaling molecules to confer cardioprotection. Various scientists have demonstrated the key role of redox signaling in cardioprotection by showing a transient increase in their levels during remote ischemic preconditioning (RIPC) phase. The transient increase in reactive oxygen species levels during remote preconditioning phase may take place either through activation of KATP channels or through increased nitric oxide (NO) production. A transient increase in reactive oxygen species during preconditioning may also increase the expression of heat shock proteins (HSP), the level of antioxidant enzymes and decrease the expression of inflammatory genes (Egr-1) during ischemia-reperfusion phase to confer cardioprotection. The present review describes the role of redox signaling in RIPC-induced cardioprotective effect with possible mechanisms.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2017.05.033