Redox signaling in remote ischemic preconditioning-induced cardioprotection: Evidences and mechanisms

• Published in: European journal of pharmacology 2017-08, Vol.809, p.151-155
• Main Authors: singh, Lovedeep, Randhawa, Puneet Kaur, Singh, Nirmal, Jaggi, Amteshwar Singh
• Format: Article
• Language: English
• Subjects: Animals; Antioxidant; Coronary Vessels - physiology; Coronary Vessels - physiopathology; Heart; Heat shock proteins; Humans; Ischemic Preconditioning; Myocardium - cytology; Myocardium - metabolism; Myocardium - pathology; Oxidation-Reduction; Reactive Oxygen Species - metabolism; Redox signaling; Remote preconditioning; Signal Transduction
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2017.05.033

Reactive oxygen species are the reactive molecules that are derived from molecular oxygen and play an important role as redox signaling molecules to confer cardioprotection. Various scientists have demonstrated the key role of redox signaling in cardioprotection by showing a transient increase in their levels during remote ischemic preconditioning (RIPC) phase. The transient increase in reactive oxygen species levels during remote preconditioning phase may take place either through activation of KATP channels or through increased nitric oxide (NO) production. A transient increase in reactive oxygen species during preconditioning may also increase the expression of heat shock proteins (HSP), the level of antioxidant enzymes and decrease the expression of inflammatory genes (Egr-1) during ischemia-reperfusion phase to confer cardioprotection. The present review describes the role of redox signaling in RIPC-induced cardioprotective effect with possible mechanisms.