MicroRNA-203 inhibits proliferation and invasion, and promotes apoptosis of osteosarcoma cells by targeting Runt-related transcription factor 2

Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2017-07, Vol.91, p.1075-1084
Main Authors: Lin, Wenjun, Zhu, Xiongbai, Yang, Shengwu, Chen, Xin, Wang, Lu, Huang, Zhengxiang, Ding, Yewei, Huang, Lintuo, Lv, Chen
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Core Binding Factor Alpha 1 Subunit - genetics
Gene Expression Regulation, Neoplastic - genetics
Humans
Internal Medicine
Invasion
Medical Education
MicroRNA-203
MicroRNAs - genetics
Neoplasm Invasiveness - genetics
Osteoblasts - pathology
Osteosarcoma
Osteosarcoma - genetics
Proliferation
RUNX2
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Summary:Highlights • MicroRNA-203 acts as a suppressor gene in osteosarcoma. • MicroRNA-203 inhibits osteosarcoma cells proliferation by directly down-regulating RUNX2. • MicroRNA-203 promotes osteosarcoma cells apoptosis by directly down-regulating RUNX2. • MicroRNA-203 inhibits osteosarcoma cells invasion by directly down-regulating RUNX2.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.05.034