Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment

Abstract Introduction Prodromal markers of Alzheimer’s disease (AD) have been derived from wakefulness. However, brain perfusion during rapid-eye movement (REM) sleep could be a sensitive marker of amnestic mild cognitive impairment (aMCI), as activation of REM sleep relies more on the cholinergic s...

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Bibliographic Details
Published in:Sleep medicine 2017-06, Vol.34, p.134-140
Main Authors: Brayet, Pauline, Petit, Dominique, Baril, Andrée-Ann, Gosselin, Nadia, Gagnon, Jean-François, Soucy, Jean-Paul, Gauthier, Serge, Kergoat, Marie-Jeanne, Carrier, Julie, Rouleau, Isabelle, Montplaisir, Jacques
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease
Amnesia - diagnostic imaging
Amnesia - physiopathology
Biomarker
Brain - diagnostic imaging
Brain - physiopathology
Cerebrovascular Circulation - physiology
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - physiopathology
Female
Humans
Male
Mild cognitive impairment
Neurology
Neuropsychological Tests
Neuropsychology
Polysomnography
Rapid-eye movement sleep
Sleep Medicine
Sleep, REM - physiology
SPECT (single-photon emission computed tomography)
Surveys and Questionnaires
Tomography, Emission-Computed, Single-Photon
Wakefulness - physiology
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Summary:Abstract Introduction Prodromal markers of Alzheimer’s disease (AD) have been derived from wakefulness. However, brain perfusion during rapid-eye movement (REM) sleep could be a sensitive marker of amnestic mild cognitive impairment (aMCI), as activation of REM sleep relies more on the cholinergic system. Methods Eight subjects with aMCI, and 16 controls, underwent two single-photon emission computed tomography (SPECT) scans with tracer injected during REM sleep then wakefulness. Results Perfusion in the anterior cingulate cortex was significantly decreased in aMCI cases compared to controls for both conditions. That defect was much larger and more severe in REM sleep (1795 voxels) compared to wakefulness (398 voxels), and extended to the middle cingulate cortex and the olfactory cortex. Hypoperfusion in the anterior cingulate cortex during REM sleep allowed better classification than hypoperfusion found in wakefulness (93.8 vs 81.3%). Conclusion REM sleep imaging is a valuable tool with which to identify individuals at risk of developing AD.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2017.01.025