Hepatitis C virus core antigen: A simplified treatment monitoring tool, including for post-treatment relapse

Highlights • HCV core antigen in plasma accurately identifies active HCV infection. • HCV core antigen detection successfully detects pre- and post-treatment viraemia. • HCV core antigen specificity is between 98 and 100% for all time-points assessed. • HCV core antigen sensitivity is 94% at baselin...

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Bibliographic Details
Published in:Journal of clinical virology 2017-07, Vol.92, p.32-38
Main Authors: Lamoury, François M.J, Soker, Angelica, Martinez, Danica, Hajarizadeh, Behzad, Cunningham, Evan B, Cunningham, Philip, Bruggmann, Philip, Foster, Graham R, Dalgard, Olav, Backmund, Markus, Conway, Brian, Robaeys, Geert, Swan, Tracy, Cloherty, Gavin, Marks, Pip, Grebely, Jason, Dore, Gregory J, Applegate, Tanya L
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antiviral Agents - therapeutic use
Core antigen
Drug Users
Female
Genotype
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - blood
Hepatitis C - diagnosis
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C Antigens - blood
Hepatitis C Antigens - genetics
Hepatitis C virus
Humans
Immunoassay - methods
Infectious Disease
Injecting drug use
Male
Middle Aged
Molecular Diagnostic Techniques - methods
People who inject drugs
Recurrence
Ribavirin - therapeutic use
RNA, Viral - blood
Sensitivity and Specificity
Simplified diagnostic
Sustained Virologic Response
Treatment Outcome
Viral Core Proteins - blood
Viral Load
Viral recurrence
Viremia - diagnosis
Viremia - drug therapy
Viremia - virology
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Description
Summary:Highlights • HCV core antigen in plasma accurately identifies active HCV infection. • HCV core antigen detection successfully detects pre- and post-treatment viraemia. • HCV core antigen specificity is between 98 and 100% for all time-points assessed. • HCV core antigen sensitivity is 94% at baseline, 100% at sustained virological response.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2017.05.007