Presence of invasive cribriform or intraductal growth at biopsy outperforms percentage grade 4 in predicting outcome of Gleason score 3+4=7 prostate cancer

Relative increase of grade 4 and presence of invasive cribriform and/or intraductal carcinoma have individually been associated with adverse outcome of Gleason score 7 (GS 7) prostate cancer. The objective of this study was to investigate the relation of Gleason grade 4 tumor percentage (%GG4) and i...

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Bibliographic Details
Published in:Modern pathology 2017-08, Vol.30 (8), p.1126-1132
Main Authors: Kweldam, Charlotte F, Kümmerlin, Intan P, Nieboer, Daan, Steyerberg, Ewout W, Bangma, Chris H, Incrocci, Luca, van der Kwast, Theodorus H, Roobol, Monique J, van Leenders, Geert J
Format: Article
Language:English
Subjects:
692/53/2423
692/700/1750/1976
Aged
Biopsy
Cancer surgery
Carcinoma, Ductal - mortality
Carcinoma, Ductal - pathology
Carcinoma, Ductal - therapy
Disease-Free Survival
Humans
Invasiveness
Kaplan-Meier Estimate
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
original-article
Pathology
Prognosis
Proportional Hazards Models
Prostate cancer
Prostate-specific antigen
Prostatectomy
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Radiation therapy
Radiotherapy
Treatment Outcome
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Summary:Relative increase of grade 4 and presence of invasive cribriform and/or intraductal carcinoma have individually been associated with adverse outcome of Gleason score 7 (GS 7) prostate cancer. The objective of this study was to investigate the relation of Gleason grade 4 tumor percentage (%GG4) and invasive cribriform and/or intraductal carcinoma in GS 3+4=7 prostate cancer biopsies. We reviewed 1031 prostate cancer biopsies from the European Randomized Study of Screening for Prostate Cancer. In total 370 men had G3+4=7. The relation of invasive cribriform and/or intraductal carcinoma and %GG4 with biochemical recurrence-free survival (BCRFS) after radical prostatectomy (n=146) and radiation therapy (n=195) was analyzed using Cox regression. Invasive cribriform and/or intraductal carcinoma occurred in 7/121 (6%) patients with 1–10% GG4, 29/131 (22%) with 10–25%, and 52/118 (44%) with 25–50% GG4 (P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2017.29