Memory Self-Appraisal and Cerebral Glucose Metabolism in Age-Associated Memory Impairment

The authors used positron emission tomography to measure cerebral glucose metabolism in 43 people with age-associated memory impairment to determine relationships between memory self-appraisal and brain function. People with lower frontal metabolism during a resting state reported more frequent prio...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry 1995, Vol.3 (2), p.132-143
Main Authors: Small, Gary W., Komo, Scott, La Rue, Asenath, Kaplan, Andrea, Mandelkern, Mark A.
Format: Article
Language:English
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Summary:The authors used positron emission tomography to measure cerebral glucose metabolism in 43 people with age-associated memory impairment to determine relationships between memory self-appraisal and brain function. People with lower frontal metabolism during a resting state reported more frequent prior mnemonics usage, a measure of memory self-appraisal. A multiple regression analysis indicated that reported mnemonics usage was the most significant predictor of left (P = 0.0004) and right (P = 0.0014) frontal metabolism. These models indicated that mnemonics usage, along with depression ratings, accounted for 39% of left frontal lobe function and, along with visual spatial memory, accounted for 40% of right frontal metabolism. These results suggest that mnemonics usage may compensate for subtle frontal dysfunction or reflect greater efficiency of memory processing.
ISSN:1064-7481
1545-7214
DOI:10.1097/00019442-199500320-00005