Comparison of the Incidences of Complications After Second-Generation Cryoballoon Ablation of Atrial Fibrillation Using Vitamin K Antagonists versus Novel Oral Anticoagulants

• Published in: The American journal of cardiology 2017-07, Vol.120 (2), p.223-229
• Main Authors: Mugnai, Giacomo, MD PhD, de Asmundis, Carlo, MD PhD, Iacopino, Saverio, MD, Stroker, Erwin, MD, Longobardi, Massimo, MD, De Regibus, Valentina, MD, Coutino-Moreno, Hugo Enrique, MD, Takarada, Ken, MD, Choudhury, Rajin, MD, Abugattas de Torres, Juan Pablo, MD, Storti, Cesare, MD PhD, Brugada, Pedro, MD PhD, Chierchia, Gian-Battista, MD PhD
• Format: Article
• Language: English
• Subjects: Ablation; Ablation Techniques - adverse effects; Administration, Oral; Antagonists; Anticoagulants; Anticoagulants - administration & dosage; Antithrombins - administration & dosage; Atrial Fibrillation - complications; Atrial Fibrillation - therapy; Belgium - epidemiology; Blood clots; Cardiac arrhythmia; Cardiovascular; Cardiovascular disease; Catheters; Complications; Cryosurgery - adverse effects; Dabigatran - administration & dosage; Dose-Response Relationship, Drug; Drug dosages; Drug resistance; Drug Therapy, Combination; Factor Xa Inhibitors - administration & dosage; Female; Fibrillation; Follow-Up Studies; Heart; Humans; Incidence; Intraoperative Period; Ischemia; Italy - epidemiology; Male; Middle Aged; Paralysis; Patients; Phrenic nerve; Postoperative Complications - epidemiology; Prognosis; Pyrazoles - administration & dosage; Pyridines - administration & dosage; Pyridones - administration & dosage; Retrospective Studies; Rivaroxaban - administration & dosage; Stroke - epidemiology; Stroke - etiology; Stroke - prevention & control; Survival Rate - trends; Thiazoles - administration & dosage; Thromboembolism; Time Factors; Vitamin K; Vitamin K - antagonists & inhibitors; Warfarin
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2017.04.012

Abstract Data evaluating the impact of the periprocedural administration of novel oral anticoagulants (NOACs) on complications in the setting of pulmonary vein (PV) isolation using cryoballoon (CB) is limited. . In the present study, our aim was to analyse procedural characteristics and incidence of complications in those patients who underwent CB ablation for atrial fibrillation (AF) and the impact of NOACs on adverse events compared to vitamin K antagonists (VKA). Consecutive patients with drug resistant AF who underwent PV isolation by CB as index procedure were retrospectively included in our analysis. In group I, 290/454 (63.9%) patients received VKAs (warfarin: n=222; acenocoumarol: n=68), and in group II, 164/454 (36.1%) patients were treated with NOACs (rivaroxaban: n=71; dabigatran: n=60; and apixaban: n=33). Age was significantly higher in the group II (62.8±9.7 vs 58.6±11.3; p