Loop Gain Predicts the Response to Upper Airway Surgery in Patients With Obstructive Sleep Apnea

Upper airway surgery is often recommended to treat patients with obstructive sleep apnea (OSA) who cannot tolerate continuous positive airways pressure. However, the response to surgery is variable, potentially because it does not improve the nonanatomical factors (ie, loop gain [LG] and arousal thr...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2017-07, Vol.40 (7)
Main Authors: Joosten, Simon A, Leong, Paul, Landry, Shane A, Sands, Scott A, Terrill, Philip I, Mann, Dwayne, Turton, Anthony, Rangaswamy, Jhanavi, Andara, Christopher, Burgess, Glen, Mansfield, Darren, Hamilton, Garun S, Edwards, Bradley A
Format: Article
Language:English
Subjects:
Adult
Arousal - physiology
Female
Humans
Male
Middle Aged
Polysomnography
Prognosis
Respiratory System - surgery
Retrospective Studies
Sleep apnea
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - surgery
Surgery
Treatment Outcome
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Summary:Upper airway surgery is often recommended to treat patients with obstructive sleep apnea (OSA) who cannot tolerate continuous positive airways pressure. However, the response to surgery is variable, potentially because it does not improve the nonanatomical factors (ie, loop gain [LG] and arousal threshold) causing OSA. Measuring these traits clinically might predict responses to surgery. Our primary objective was to test the value of LG and arousal threshold to predict surgical success defined as 50% reduction in apnea-hypopnea index (AHI) and AHI
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsx094