Comparison of the Immunity Status in-Between Children with beta -Thalassaemia Major Receiving Different Treatment Modalities: A Single Egyptian District Study

• Published in: Immunome research 2017-01, Vol.13 (1), p.1-1
• Main Authors: Mahmoud, S S, Mohamed, G B, Hakeem, G L A, Higazi, A M, Nafady, A A H, Farag, N M, Mahrous, D M, Kamal, N N, Hassan, Z, Aziz, E A, Shaban, A
• Format: Article
• Language: English
• ISSN: 1745-7580; 1745-7580
• DOI: 10.4172/1745-7580.1000127

s-thalassaemia major is one of the chronic hemolytic anemias resulting from defect in s-globin chain. It requires frequent blood transfusion plus other treatment modalities. These treatment modalities may be associated with certain immunologic modulations. To assess the immunity status in children with s-thalassaemia major under different treatment regimens within El Minia, Egypt. One hundred forty-four children were enrolled and classified into four groups. Thirty-six s-thalassaemia patients treated only with blood transfusion (group I). Thirty-six patients treated with transfusion and iron chelation (group II). Thirty-six patients treated with transfusion, iron chelation and subjected to splenectomy (group III). Group IV involved thirty-six apparently healthy age and sex matched children. CBC plus serum levels of ferritin, IgA, complement C3 and C4 were measured along with detection of CD3+, CD4+, CD8+, CD19+ and CD56+ lymphocyte percentages and absolute counts. IgA levels were significantly higher in thalassaemia patients compared to controls (p