Effective and safe mannitol administration in patients undergoing supratentorial tumor surgery: A prospective, randomized and double blind study

Highlights • The mannitol and furosemide-mannitol combination provides similar degree brain relaxation in supratentorial tumor surgery. • Furosemide with low or high doses of mannitol may cause electrolyte imbalance and high lactate levels. • Moreover high urine out-put and negative intra-operative...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2017-08, Vol.159, p.55-61
Main Authors: Akcil, Eren Fatma, Dilmen, Ozlem Korkmaz, Karabulut, Esra Sultan, Koksal, Serdar Selcuk, Altindas, Fatis, Tunali, Yusuf
Format: Article
Language:English
Subjects:
Adult
Anesthesiology
Blood
Brain
Brain cancer
Brain relaxation
Catheters
Chlorides
Clinical trials
Craniotomy - trends
Diabetes
Diuresis
Diuretics
Diuretics, Osmotic - administration & dosage
Double-Blind Method
Double-blind studies
Drug dosages
Elective Surgical Procedures - trends
Electrolytes
Female
Furosemide
Furosemide - administration & dosage
Humans
Intensive care
Lactic acid
Male
Mannitol
Mannitol - administration & dosage
Middle Aged
Neurology
Neurosurgery
Osmolarity
Patients
Prospective Studies
Side effects
Sodium
Statistical analysis
Supratentorial Neoplasms - blood
Supratentorial Neoplasms - drug therapy
Supratentorial Neoplasms - surgery
Supratentorial tumor surgery
Surgery
Surgical outcomes
Traumatic brain injury
Treatment Outcome
Tumors
Urine
Variance analysis
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Summary:Highlights • The mannitol and furosemide-mannitol combination provides similar degree brain relaxation in supratentorial tumor surgery. • Furosemide with low or high doses of mannitol may cause electrolyte imbalance and high lactate levels. • Moreover high urine out-put and negative intra-operative fluid balance may occur. • 0.5 g kg−1 mannitol provides enough brain relaxation without causing systemic side effects.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2017.05.018