A Critical Review on Ultrasensitive, Spectroscopic-based Methods for High-throughput Monitoring of Bacteria during Infection Treatment

The world is in the midst of a pre-emptive public health emergency, one that is just as dramatic as the global aggressive viruses-related crises (Ebola, Zika, or SARS), but not as visible. The "superbugs" and their antimicrobial resistance do not cause much public alarm or awareness, but p...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in analytical chemistry 2017-11, Vol.47 (6), p.499-512
Main Authors: Dina, Nicoleta Elena, Colniţă, Alia, Szöke-Nagy, Tiberiu, Porav, Alin Sebastian
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
Bacteria - chemistry
Bacterial Infections - diagnosis
Bacterial Infections - microbiology
Cell culture
high-throughput monitoring
Humans
Infections
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Monitoring
mycobacteria
Nanotechnology
Public health
Silver - chemistry
Single-Cell Analysis
Spectrum analysis
Spectrum Analysis, Raman
ultrasensitive spectroscopy
Vector-borne diseases
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The world is in the midst of a pre-emptive public health emergency, one that is just as dramatic as the global aggressive viruses-related crises (Ebola, Zika, or SARS), but not as visible. The "superbugs" and their antimicrobial resistance do not cause much public alarm or awareness, but provoke financial losses of $100 trillion annually (WHO, http://www.who.int/mediacentre/commentaries/superbugs-action-now/en/ ). This status quo review offers an overview of ultrasensitive methods for high-throughput monitoring of bacteria during infection treatment, the effects of antibiotics on bacteria at single-cell level and the challenges we will face in their detection due to the extraordinary capability of these "superbugs" to gain and constantly improve multiresistance to antibiotics. A special emphasis is put on the ultrasensitive spectroscopic-based analysis techniques, using nanotechnology or not necessarily, that are more and more promising alternatives to conventional culture-based ones. The particular case of Mycobacteria detection is discussed based on recent reported work.
ISSN:1040-8347
1547-6510
DOI:10.1080/10408347.2017.1332974