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Changes in viral hepatitis B screening practices over time in West African HIV clinics

We aimed to describe changes in hepatitis B screening practices over a 3-year period among HIV-infected patients in West Africa. A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who star...

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Published in:Médecine et maladies infectieuses 2017-10, Vol.47 (6), p.394-400
Main Authors: Coffie, P.A., Patassi, A., Doumbia, A., Bado, G., Messou, E., Minga, A., Allah-Kouadio, E., Zannou, D.M., Seydi, M., Kakou, A.R., Dabis, F., Wandeler, G.
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creator Coffie, P.A.
Patassi, A.
Doumbia, A.
Bado, G.
Messou, E.
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Allah-Kouadio, E.
Zannou, D.M.
Seydi, M.
Kakou, A.R.
Dabis, F.
Wandeler, G.
description We aimed to describe changes in hepatitis B screening practices over a 3-year period among HIV-infected patients in West Africa. A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who started antiretroviral treatment between 2010 and 2012, 100 per year were randomly selected from each clinic. Demographic, clinical, and laboratory data was collected using a standardized questionnaire. We assessed changes in the proportion of patients screened over time and identified predictors of screening in a multivariable logistic regression. A total of 2097 patients were included (median age: 37 years, 65.4% of women). Overall, 313 (14.9%) patients had been screened for hepatitis B, with an increase from 10.6% in 2010 to 18.9% in 2012 (P
doi_str_mv 10.1016/j.medmal.2017.04.011
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A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who started antiretroviral treatment between 2010 and 2012, 100 per year were randomly selected from each clinic. Demographic, clinical, and laboratory data was collected using a standardized questionnaire. We assessed changes in the proportion of patients screened over time and identified predictors of screening in a multivariable logistic regression. A total of 2097 patients were included (median age: 37 years, 65.4% of women). Overall, 313 (14.9%) patients had been screened for hepatitis B, with an increase from 10.6% in 2010 to 18.9% in 2012 (P&lt;0.001) and substantial differences across countries. In multivariable analysis, being aged over 45 years (adjusted odds ratio: 1.34 [1.01–1.77]) and having an income-generating activity (adjusted odds ratio: 1.82 [1.09–3.03]) were associated with screening for hepatitis B infection. Overall, 62 HIV-infected patients (19.8%, 95% confidence interval: 15.5–24.7) were HBsAg-positive and 82.3% of them received a tenofovir-containing drug regimen. Hepatitis B screening among HIV-infected patients was low between 2010 and 2012. The increasing availability of HBsAg rapid tests and tenofovir in first-line antiretroviral regimen should improve the rates of hepatitis B screening. Décrire les pratiques de dépistage de l’hépatite B au cours du temps chez les patients infectés par le VIH en Afrique de l’Ouest. Une enquête a été menée dans les centres urbains de prise en charge du VIH en Côte d’Ivoire (3 sites), Bénin, Burkina Faso, Sénégal et Togo (1 site chacun). Parmi les patients ayant été mis sous traitement antirétroviral entre 2010 et 2012, 100 ont été tirés au sort chaque année dans chaque clinique. Les informations ont été recueillies à partir des dossiers médicaux. Les facteurs associés au dépistage de l’hépatite B ont été recherchés par régression logistique. Au total, 2097 patients ont été inclus (âge médian de 37 ans, 65,4 % de femmes). Le dépistage de l’hépatite B a été réalisé chez 313 (14,9 %) patients, avec une augmentation au cours du temps (de 10,6 % en 2010 à 18,9 % en 2012, p&lt;0,001), et une variation entre les centres. Un âge&gt;45 ans (rapport de cotes ajusté : 1,34 [1,01–1,77]) et une activité génératrice de revenus (rapport de cotes ajusté : 1,82 [1,09–3,03]) étaient associés au dépistage de l’hépatite B. La prévalence de l’hépatite B chronique (AgHBs+) était de 19,8 % (15,5–24,7) et 82,3 % des co-infectés étaient traités par ténofovir. Entre 2010 et 2012, le dépistage de l’hépatite B chez les patients infectés par le VIH était faible. La disponibilité croissante des tests rapides de recherche de l’AgHBs et du ténofovir devrait améliorer ce dépistage.</description><identifier>ISSN: 0399-077X</identifier><identifier>EISSN: 1769-6690</identifier><identifier>DOI: 10.1016/j.medmal.2017.04.011</identifier><identifier>PMID: 28545675</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>Adult ; Africa, Western - epidemiology ; Afrique subsaharienne ; Alanine Transaminase - blood ; Anti-Retroviral Agents - administration &amp; dosage ; Antiretroviral agents ; CD4 Lymphocyte Count ; Confidence intervals ; Demographics ; Dépistage ; Female ; HBV ; Hepatitis ; Hepatitis B ; Hepatitis B - complications ; Hepatitis B - diagnosis ; Hepatitis B - epidemiology ; Hepatitis B surface antigen ; Hepatitis B Surface Antigens - blood ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV-1 - isolation &amp; purification ; HIV-2 - isolation &amp; purification ; HIV-infected patients ; Human immunodeficiency virus ; Humans ; Male ; Mass Screening - trends ; Medical screening ; Medical treatment ; Middle Aged ; Patients ; Patients infectés par le VIH ; Prevalence ; Regression analysis ; Retrospective Studies ; Risk Factors ; Screening ; Statistical analysis ; Sub-Saharan Africa ; Surveys and Questionnaires ; Tenofovir ; VHB</subject><ispartof>Médecine et maladies infectieuses, 2017-10, Vol.47 (6), p.394-400</ispartof><rights>2017 Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Oct 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-9d09f2fad47bdb936e4271c7abcb696cf7e729ea07648517c992bf8d48d6b2553</citedby><cites>FETCH-LOGICAL-c366t-9d09f2fad47bdb936e4271c7abcb696cf7e729ea07648517c992bf8d48d6b2553</cites><orcidid>0000-0002-6486-2991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28545675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coffie, P.A.</creatorcontrib><creatorcontrib>Patassi, A.</creatorcontrib><creatorcontrib>Doumbia, A.</creatorcontrib><creatorcontrib>Bado, G.</creatorcontrib><creatorcontrib>Messou, E.</creatorcontrib><creatorcontrib>Minga, A.</creatorcontrib><creatorcontrib>Allah-Kouadio, E.</creatorcontrib><creatorcontrib>Zannou, D.M.</creatorcontrib><creatorcontrib>Seydi, M.</creatorcontrib><creatorcontrib>Kakou, A.R.</creatorcontrib><creatorcontrib>Dabis, F.</creatorcontrib><creatorcontrib>Wandeler, G.</creatorcontrib><title>Changes in viral hepatitis B screening practices over time in West African HIV clinics</title><title>Médecine et maladies infectieuses</title><addtitle>Med Mal Infect</addtitle><description>We aimed to describe changes in hepatitis B screening practices over a 3-year period among HIV-infected patients in West Africa. A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who started antiretroviral treatment between 2010 and 2012, 100 per year were randomly selected from each clinic. Demographic, clinical, and laboratory data was collected using a standardized questionnaire. We assessed changes in the proportion of patients screened over time and identified predictors of screening in a multivariable logistic regression. A total of 2097 patients were included (median age: 37 years, 65.4% of women). Overall, 313 (14.9%) patients had been screened for hepatitis B, with an increase from 10.6% in 2010 to 18.9% in 2012 (P&lt;0.001) and substantial differences across countries. In multivariable analysis, being aged over 45 years (adjusted odds ratio: 1.34 [1.01–1.77]) and having an income-generating activity (adjusted odds ratio: 1.82 [1.09–3.03]) were associated with screening for hepatitis B infection. Overall, 62 HIV-infected patients (19.8%, 95% confidence interval: 15.5–24.7) were HBsAg-positive and 82.3% of them received a tenofovir-containing drug regimen. Hepatitis B screening among HIV-infected patients was low between 2010 and 2012. The increasing availability of HBsAg rapid tests and tenofovir in first-line antiretroviral regimen should improve the rates of hepatitis B screening. Décrire les pratiques de dépistage de l’hépatite B au cours du temps chez les patients infectés par le VIH en Afrique de l’Ouest. Une enquête a été menée dans les centres urbains de prise en charge du VIH en Côte d’Ivoire (3 sites), Bénin, Burkina Faso, Sénégal et Togo (1 site chacun). Parmi les patients ayant été mis sous traitement antirétroviral entre 2010 et 2012, 100 ont été tirés au sort chaque année dans chaque clinique. Les informations ont été recueillies à partir des dossiers médicaux. Les facteurs associés au dépistage de l’hépatite B ont été recherchés par régression logistique. Au total, 2097 patients ont été inclus (âge médian de 37 ans, 65,4 % de femmes). Le dépistage de l’hépatite B a été réalisé chez 313 (14,9 %) patients, avec une augmentation au cours du temps (de 10,6 % en 2010 à 18,9 % en 2012, p&lt;0,001), et une variation entre les centres. Un âge&gt;45 ans (rapport de cotes ajusté : 1,34 [1,01–1,77]) et une activité génératrice de revenus (rapport de cotes ajusté : 1,82 [1,09–3,03]) étaient associés au dépistage de l’hépatite B. La prévalence de l’hépatite B chronique (AgHBs+) était de 19,8 % (15,5–24,7) et 82,3 % des co-infectés étaient traités par ténofovir. Entre 2010 et 2012, le dépistage de l’hépatite B chez les patients infectés par le VIH était faible. 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A medical chart review was conducted in urban HIV treatment centers in Ivory Coast (3 sites), Benin, Burkina Faso, Senegal, and Togo (1 site each). Among patients who started antiretroviral treatment between 2010 and 2012, 100 per year were randomly selected from each clinic. Demographic, clinical, and laboratory data was collected using a standardized questionnaire. We assessed changes in the proportion of patients screened over time and identified predictors of screening in a multivariable logistic regression. A total of 2097 patients were included (median age: 37 years, 65.4% of women). Overall, 313 (14.9%) patients had been screened for hepatitis B, with an increase from 10.6% in 2010 to 18.9% in 2012 (P&lt;0.001) and substantial differences across countries. In multivariable analysis, being aged over 45 years (adjusted odds ratio: 1.34 [1.01–1.77]) and having an income-generating activity (adjusted odds ratio: 1.82 [1.09–3.03]) were associated with screening for hepatitis B infection. Overall, 62 HIV-infected patients (19.8%, 95% confidence interval: 15.5–24.7) were HBsAg-positive and 82.3% of them received a tenofovir-containing drug regimen. Hepatitis B screening among HIV-infected patients was low between 2010 and 2012. The increasing availability of HBsAg rapid tests and tenofovir in first-line antiretroviral regimen should improve the rates of hepatitis B screening. Décrire les pratiques de dépistage de l’hépatite B au cours du temps chez les patients infectés par le VIH en Afrique de l’Ouest. Une enquête a été menée dans les centres urbains de prise en charge du VIH en Côte d’Ivoire (3 sites), Bénin, Burkina Faso, Sénégal et Togo (1 site chacun). Parmi les patients ayant été mis sous traitement antirétroviral entre 2010 et 2012, 100 ont été tirés au sort chaque année dans chaque clinique. Les informations ont été recueillies à partir des dossiers médicaux. Les facteurs associés au dépistage de l’hépatite B ont été recherchés par régression logistique. Au total, 2097 patients ont été inclus (âge médian de 37 ans, 65,4 % de femmes). Le dépistage de l’hépatite B a été réalisé chez 313 (14,9 %) patients, avec une augmentation au cours du temps (de 10,6 % en 2010 à 18,9 % en 2012, p&lt;0,001), et une variation entre les centres. Un âge&gt;45 ans (rapport de cotes ajusté : 1,34 [1,01–1,77]) et une activité génératrice de revenus (rapport de cotes ajusté : 1,82 [1,09–3,03]) étaient associés au dépistage de l’hépatite B. La prévalence de l’hépatite B chronique (AgHBs+) était de 19,8 % (15,5–24,7) et 82,3 % des co-infectés étaient traités par ténofovir. Entre 2010 et 2012, le dépistage de l’hépatite B chez les patients infectés par le VIH était faible. La disponibilité croissante des tests rapides de recherche de l’AgHBs et du ténofovir devrait améliorer ce dépistage.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>28545675</pmid><doi>10.1016/j.medmal.2017.04.011</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6486-2991</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0399-077X
ispartof Médecine et maladies infectieuses, 2017-10, Vol.47 (6), p.394-400
issn 0399-077X
1769-6690
language eng
recordid cdi_proquest_miscellaneous_1903170531
source ScienceDirect Journals
subjects Adult
Africa, Western - epidemiology
Afrique subsaharienne
Alanine Transaminase - blood
Anti-Retroviral Agents - administration & dosage
Antiretroviral agents
CD4 Lymphocyte Count
Confidence intervals
Demographics
Dépistage
Female
HBV
Hepatitis
Hepatitis B
Hepatitis B - complications
Hepatitis B - diagnosis
Hepatitis B - epidemiology
Hepatitis B surface antigen
Hepatitis B Surface Antigens - blood
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV-1 - isolation & purification
HIV-2 - isolation & purification
HIV-infected patients
Human immunodeficiency virus
Humans
Male
Mass Screening - trends
Medical screening
Medical treatment
Middle Aged
Patients
Patients infectés par le VIH
Prevalence
Regression analysis
Retrospective Studies
Risk Factors
Screening
Statistical analysis
Sub-Saharan Africa
Surveys and Questionnaires
Tenofovir
VHB
title Changes in viral hepatitis B screening practices over time in West African HIV clinics
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