Social and academic premorbid adjustment domains predict different functional outcomes among youth with first episode mania

Abstract Background Premorbid characteristics may help predict the highly variable functional and illness outcomes of young people with early stage Bipolar Disorder (BD). We sought to examine the relationships between premorbid adjustment and short to medium-term outcomes after a first treated episo...

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Bibliographic Details
Published in:Journal of affective disorders 2017-09, Vol.219, p.133-140
Main Authors: Ratheesh, Aswin, Davey, Christopher G, Daglas, Rothanthi, Macneil, Craig, Hasty, Melissa, Filia, Kate, McGorry, Patrick D, Berk, Michael, Conus, Philippe, Cotton, Sue
Format: Article
Language:English
Subjects:
Academic Performance - psychology
Adolescent
Adult
Bipolar
Bipolar Disorder - psychology
Depression
Female
Functioning
Humans
Male
Prediction
Premorbid adjustment
Psychiatry
Psychotic Disorders - psychology
Psychotic mania
Quality of Life
Social Adjustment
Surveys and Questionnaires
Victoria
Young Adult
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Summary:Abstract Background Premorbid characteristics may help predict the highly variable functional and illness outcomes of young people with early stage Bipolar Disorder (BD). We sought to examine the relationships between premorbid adjustment and short to medium-term outcomes after a first treated episode of mania. Methods We examined the baseline and 18-month follow-up characteristics of 117 participants with first episode of mania, treated at two tertiary early intervention services in Melbourne, Australia. The baseline demographic, family history, diagnoses, comorbidity and clinical features were determined using unstructured questionnaires and structured diagnostic interviews. Premorbid adjustment was determined using the Premorbid Adjustment Scale (PAS), the components of which were identified using a principal component analysis. Eighteen-month follow-up outcome measures included the Clinical Global Impressions scale, Social and Occupational Functioning Assessment Scale and the Heinrichs’ Quality of Life Scale (QLS). Correlations and linear regressions were utilised to examine the relationships between component scores and outcomes, while controlling for baseline and follow-up confounders. Results The social adjustment component of the PAS correlated with the interpersonal relations ( r s = −0.46, p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2017.05.030