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Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection

The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infe...

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Bibliographic Details
Published in:Lung 2017-08, Vol.195 (4), p.517-521
Main Authors: Ordoñez, Ciara, Tarajia, Musharaf, Rivera, René, Sambrano, Dilcia, Batista, Victoria, Chávez, Mónica, Tapia, Denis, Fernández, Patricia L., Goodridge, Amador
Format: Article
Language:English
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Summary:The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance. Our findings suggest that IgM antibodies are secreted and their composition vary during early and late immune response to BCG pleurisy.
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-017-0019-0