MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma

• Published in: Journal of neuro-oncology 2017-07, Vol.133 (3), p.553-559
• Main Authors: Zhang, Jun, Lv, Jianguang, Zhang, Feng, Che, Hongmin, Liao, Qiwei, Huang, Wobin, Li, Shaopeng, Li, Yuqian
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - metabolism; Brain - metabolism; Brain - pathology; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Brain tumors; Classification; Clinical Study; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioma; Glioma - metabolism; Glioma - pathology; Glioma - therapy; Humans; Kaplan-Meier Estimate; Male; Medical prognosis; Medicine; Medicine & Public Health; MicroRNAs; MicroRNAs - metabolism; Middle Aged; miRNA; Multivariate Analysis; Neoplasm Grading; Neurology; Oncology; Polymerase chain reaction; Prognosis; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Risk factors; Survival
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/s11060-017-2464-2

Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well as its correlation with patient prognosis. Glioma tissues and adjacent normal brain tissues were obtained from 82 patients who underwent surgical resection, and quantitative real-time polymerase chain reaction was performed to assess the expression level of miR-211. Here, we found that miR-211 was significantly decreased in glioma tissues compared with adjacent normal brain tissues (glioma, 3.52 ± 0.14 vs. normal, 4.96 ± 0.17, p