Emerging extended-spectrum β-lactamase-producing Klebsiella pneumoniae causing community-onset urinary tract infections: a case–control–control study

• Published in: International journal of antimicrobial agents 2017-08, Vol.50 (2), p.197-202
• Main Authors: Boix-Palop, Lucía, Xercavins, Mariona, Badía, Cristina, Obradors, Meritxell, Riera, Montserrat, Freixas, Núria, Pérez, Josefa, Rodríguez-Carballeira, Mónica, Garau, Javier, Calbo, Esther
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; beta-Lactamases - genetics; Case-Control Studies; Communicable Diseases, Emerging - epidemiology; Communicable Diseases, Emerging - microbiology; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Community-onset; CTX-M-15; Extended-spectrum β-lactamase; Female; Humans; Infectious Disease; Klebsiella Infections - epidemiology; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - isolation & purification; Male; Middle Aged; Multiplex Polymerase Chain Reaction; Prevalence; Retrospective Studies; Risk Factors; Sequence Analysis, DNA; Urinary tract infection; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; Young Adult
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2017.03.009

Highlights • Prevalence of community-onset UTI (CO-UTI) due to ESBL-producing K. pneumoniae (ESBL-Kp) is increasing. • CTX-M-15 enzymes appear to have replaced older types of ESBLs in K. pneumoniae. • Almost two-thirds of CO-UTIs due to ESBL-Kp are community-acquired. • Exposure to cephalosporins is a risk factor for CO-UTI due to ESBL-Kp. • Being a nursing home resident is a risk factor for CO-UTI due to ESBL-Kp.