Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2

Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are...

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Bibliographic Details
Published in:Journal of general virology 2017-05, Vol.98 (5), p.1073-1079
Main Authors: López-Bueno, Alberto, Parras-Moltó, Marcos, López-Barrantes, Olivia, Belda, Sylvia, Alejo, Alí
Format: Article
Language:English
Subjects:
Child
Cluster Analysis
Genome, Viral
Healthy Volunteers
High-Throughput Nucleotide Sequencing
Humans
Molluscum contagiosum virus - classification
Molluscum contagiosum virus - genetics
Molluscum contagiosum virus - growth & development
Molluscum contagiosum virus - isolation & purification
Phylogeny
Recombination, Genetic
Sequence Analysis, DNA
Sequence Homology
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Summary:Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Comparisons suggest a relatively distant evolutionary split between both MCV subtypes. Further, our data illustrate concurrent circulation of distinct viruses within a population and reveal the existence of recombination events among them. These results help identify a set of MCV genes with potentially relevant roles in molluscum contagiosum epidemiology and pathogenesis.
ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.000759