Association between obesity phenotypes and incident hypertension among Chinese adults: a prospective cohort study

Abstract Objectives To explore the association between obesity phenotype and the risk of hypertension among Chinese adults. Study design A prospective cohort study. Methods Two waves of data were collected in 2009 and 2011 by the China Health Nutrition Survey. According to International Diabetes Fed...

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Bibliographic Details
Published in:Public health (London) 2017-08, Vol.149, p.65-70
Main Authors: Cao, Z.K, Huang, Y, Yu, H.J, Yuan, S, Tang, B.W, Li, Q.X, Li, X.T, Yang, X.H, He, Q.Q
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Amine oxidase (flavin-containing)
Body weight
China - epidemiology
Cohort analysis
Confidence intervals
Diabetes
Diabetes mellitus
Federations
Female
Founders
Genotype & phenotype
Health Surveys
Humans
Hypertension
Hypertension - epidemiology
Incidence
Infectious Disease
Internal Medicine
Male
Metabolic syndrome
Middle Aged
Nutrition
Obesity
Overweight
Phenotype
Phenotypes
Prospective Studies
Regression models
Risk Assessment
Risk factors
Statistical analysis
Young Adult
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Summary:Abstract Objectives To explore the association between obesity phenotype and the risk of hypertension among Chinese adults. Study design A prospective cohort study. Methods Two waves of data were collected in 2009 and 2011 by the China Health Nutrition Survey. According to International Diabetes Federation and Chinese obesity criteria, participants were divided into four groups: metabolically healthy non-overweight/obesity (MHNO), metabolically healthy overweight/obesity (MHO), metabolically abnormal non-overweight/obesity (MANO), and metabolically abnormal overweight/obesity (MAO). Logistic regression model was performed to estimate the risk of hypertension with obesity phenotype. Results Among a total of 4604 adults aged 18–65 years at baseline, 467 developed hypertension during the 2-year follow-up period. After adjusting for several potential confounders, significantly increased risks for hypertension were found for participants in MHO (odd ratio [OR]: 1.78, 95% confidence interval [CI]: 1.39–2.27), MANO (OR: 1.71, 95% CI: 1.02–2.86), and MAO (OR: 3.35, 95% CI: 2.54–4.42) group compared with the MHNO group. Conclusion Metabolically abnormal individuals, regardless of their body weight status, showed significantly higher risks for hypertension compared with healthy non-overweight/obese group. Furthermore, MHO individuals had significantly increased risk of incident hypertension.
ISSN:0033-3506
1476-5616
DOI:10.1016/j.puhe.2017.04.018