Correlations of Foxo3 and Foxo4 expressions with clinicopathological features and prognosis of bladder cancer

The study is performed to explore the correlations of forkhead box O3 (FoxO3) and forkhead box O4 (FoxO4) expressions with clinicopathological features and prognosis of bladder cancer. Bladder cancer tissues and adjacent normal tissues from the recruited 222 patients were collected. Quantitative rea...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2017-07, Vol.213 (7), p.766-772
Main Authors: Wang, Yang, Kang, Xin-Li, Zeng, Fan-Chang, Xu, Cong-Jie, Zhou, Jia-Quan, Luo, Dong-Ni
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Bladder cancer
Blotting, Western
Clinicopathological features
Cystectomy
Disease Progression
Disease-Free Survival
Female
Forkhead box O3
Forkhead box O4
Forkhead Box Protein O3 - analysis
Forkhead Box Protein O3 - genetics
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Proportional Hazards Models
Real-Time Polymerase Chain Reaction
Risk Factors
Time Factors
Transcription Factors - analysis
Transcription Factors - genetics
Treatment Outcome
Urinary Bladder Neoplasms - chemistry
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
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Summary:The study is performed to explore the correlations of forkhead box O3 (FoxO3) and forkhead box O4 (FoxO4) expressions with clinicopathological features and prognosis of bladder cancer. Bladder cancer tissues and adjacent normal tissues from the recruited 222 patients were collected. Quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting and immunohistochemistry were applied to determine the expressions of FoxO3 and FoxO4. Spearman correlation analysis was conducted to examine the correlation between the expressions of FoxO3 and FoxO4. All patients were followed up and overall survival (OS) and disease-free survival (DFS) were recorded. Kaplan-Meier survival curve was drawn to determine the associations of FoxO3 and FoxO4 expressions and postoperative survival. Cox proportional hazards model was conducted to analyze the risk factors for poor prognosis of bladder cancer. The mRNA and expressions of FoxO3 and FoxO4 proteins in the bladder cancer tissues were lower than that in the adjacent normal tissues (both P
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2017.04.004