Some Reflections on Neuropathies

• Published in: Clinical therapeutics 2017-06, Vol.39 (6), p.1077-1080
• Main Author: Shader, Richard I., MD
• Format: Article
• Language: English
• Subjects: Acetaminophen; Activation; Adults; Age; Allergies; Amine oxidase (flavin-containing); Anticonvulsants; Antidepressants; Aromatic-L-amino-acid decarboxylase; Bells; Blistering; Burning; Carpal tunnel syndrome; Central nervous system; Cerebellum; Children; Classification; Combustion; Cooking; Corpus striatum; Demyelination; Diabetes; Diabetes mellitus; Diabetic neuropathy; Diagnosis; Dopamine; Food; Ganglia; Heating; Hemorrhage; Herpes zoster; Immunological tolerance; Incidence; Inhibitors; Injuries; Internal Medicine; Lesions; Medical Education; Metabolism; Metabolites; Nervous system; Nursing; Nutrient content; Nutrients; Nutrition; Older people; Overuse injuries; Pain; Pain perception; Peripheral neuropathy; Phosphates; Pregnancy; Preservation; Proprioception; Receiving; Sensory neurons; Spinal cord; Stem cells; Steroids; Stimulation
• ISSN: 0149-2918; 1879-114X
• DOI: 10.1016/j.clinthera.2017.05.004

There are virus-induced hemorrhagic, fibrotic, and degenerative changes in the posterior (dorsal) root ganglia of the spinal cord accompanied by the loss of afferent input from sensory nerve endings. Because the symptoms lasted longer than might be caused by the direct effects of the anesthetic agent on the nerve, it is likely that there was physical damage to the nerve from the lumbar epidural. Requirements increase with age, ranging from 0.1 mg/d in newborns to about 1.5 mg/d in older adults; about 2.0 mg/d is recommended during pregnancy or for nursing mothers.11 I have wondered if supplemental B6 would have been beneficial for Ms. W or Ms. X or Mr. Y. Given the current craze for hummus products, one should know that chickpeas (garbanzo Type 2 Diabetes Mellitus. Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial. 1 R.G. Kost, S.E. Straus, Postherpetic neuralgia--pathogenesis, treatment, and prevention, N Engl J Med, Vol. 335, 1996, 32-42 2 Neuralgia, The Shorter Oxford English Dictionary, 1980, Clarendon Press, Oxford, UK, 1398 3 Neuralgia. https://en.wikipedia.org/wiki/Neuralgia, . 5 H. Marsh, Do No Harm, 2015, New York 6 R.I. Shader, D.J. Greenblatt, Phenelzine and the dream machine-ramblings and reflections, J Clin Psychopharmacol, Vol. 5, 1985, 65-70 7 N.H. Raskin, R.A. Fishman, Pyridoxine-deficiency neuropathy due to hydralazine, N Engl J Med, Vol. 273, 1965, 1182-1185 8 C.A. Heller, P.A. Friedman, Pyridoxine deficiency and peripheral neuropathy associated...