Changes of cortical activation in swallowing following high frequency repetitive transcranial magnetic stimulation in older adults

Background This study explored whether high‐frequency repetitive transcranial magnetic stimulation (rTMS) can induce positive changes in the cortical areas of older adults who do not have functional difficulties in swallowing. Methods Ten healthy, right‐handed, elderly volunteers were subjected to 1...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2017-11, Vol.29 (11), p.n/a
Main Authors: Park, J.‐W., Sim, G.‐J., Kim, H.‐J., Yeo, J.‐S., Hong, H.‐J., Kwon, B. S.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
Deglutition
Drinking
Female
Geriatrics
Handedness
Hemispheric laterality
Humans
Magnetic fields
Male
neurophysiology
Older people
Pharynx
Pharynx - physiology
Positron emission tomography
Sensorimotor Cortex - diagnostic imaging
Sensorimotor Cortex - physiology
Somatosensory cortex
Statistics
Swallowing
Transcranial Magnetic Stimulation
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Summary:Background This study explored whether high‐frequency repetitive transcranial magnetic stimulation (rTMS) can induce positive changes in the cortical areas of older adults who do not have functional difficulties in swallowing. Methods Ten healthy, right‐handed, elderly volunteers were subjected to 18F‐labeled fluorodeoxyglucose positron emission tomography(FDG‐PET) scans when at rest, swallowing before rTMS, and swallowing after rTMS. During the swallowing study, water was infused orally via a catheter at a rate of 600 mL/h. Subjects swallowed water every 20 seconds following a light flash for 30 minutes. During rest, the light source was active, but subjects were requested not to swallow. The rTMS consisted of 5 Hz applied to a pharyngeal motor hot spot in the right hemisphere for 10 minutes every weekday for 2 weeks. The intensity of the stimulation was set at 90% of the thenar motor threshold of the same hemisphere. The differences between each patient's active image and the control images (P
ISSN:1350-1925
1365-2982
DOI:10.1111/nmo.13123