An easily accessible aggregation-induced emission probe for lipid droplet-specific imaging and movement tracking

Lipid droplets (LDs) as dynamic organelles are associated with many metabolic processes. Ideal fluorescent probes for LD-specific imaging require excellent specificity, superior brightness, fast cell permeability, and easy preparation. However, conventional fluorophores for LD imaging suffer from dr...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-01, Vol.53 (5), p.921-924
Main Authors: Gao, Meng, Su, Huifang, Li, Shiwu, Lin, Yuhan, Ling, Xia, Qin, Anjun, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
Accessibility
Droplets
Dynamics
Emission
Fluorescence
Imaging
Lipids
Tracking
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Summary:Lipid droplets (LDs) as dynamic organelles are associated with many metabolic processes. Ideal fluorescent probes for LD-specific imaging require excellent specificity, superior brightness, fast cell permeability, and easy preparation. However, conventional fluorophores for LD imaging suffer from drawbacks of aggregation-caused quenching (ACQ), poor photostability, and difficulty of preparation. To tackle these challenges, herein, we develop an easily accessible aggregation-induced emission (AIE) fluorescent probe for LD-specific imaging and dynamic movement tracking. This AIE probe has significant advantages in terms of fast cell permeability, low cytotoxicity, strong photostability, and high two-photon absorption cross-sections in the near infra-red (NIR) range. It is thus expected to have broad applications in the study of LDs' biological functions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09471f