Interference‐Free Surface‐Enhanced Raman Scattering Tags for Single‐Cell Molecular Imaging with a High Signal‐to‐Background Ratio

An interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the...

Full description

Saved in:
Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2017-04, Vol.13 (15), p.np-n/a
Main Authors: Ma, Sisi, Li, Qiang, Yin, Yongmei, Yang, Jie, Liu, Dingbin
Format: Article
Language:English
Subjects:
bioimaging
Biomarkers
Cancer
core–shell nanostructures
Desorption
Gold
gold nanoparticles
Interference
Nanoparticles
nanoprobes
Nanotechnology
Raman scattering
SERS nanotags
Tags
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An interference‐free surface‐enhanced Raman scattering tag is constructed to profile the expression of cancer biomarkers at the single‐cell level. The Raman tags present a strong and sharp peak in the cellular Raman‐silent region, significantly diminishing the background interference. Moreover, the reporters are embedded in the layered gold nanoparticles, avoiding desorption and enzymatic degradation in physiological conditions.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201603340