Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coilin...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-04, Vol.53 (32), p.4509-4512
Main Authors: Limón, David, Jiménez-Newman, Claire, Calpena, Ana C, González-Campo, Arántzazu, Amabilino, David B, Pérez-García, Lluïsa
Format: Article
Language:English
Subjects:
Administration, Topical
Cationic
Cations - administration & dosage
Cations - chemistry
Cations - pharmacology
Coiling
Drug delivery systems
Drug Liberation - drug effects
Fibers
Gels
Humans
Hydrogels
Hydrogels - administration & dosage
Hydrogels - chemistry
Hydrogels - pharmacology
Imidazoles - administration & dosage
Imidazoles - chemistry
Imidazoles - pharmacology
Macromolecular Substances - administration & dosage
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Molecular Structure
Particle Size
Penetration
Protease inhibitors
Serine Proteinase Inhibitors - chemistry
Serine Proteinase Inhibitors - pharmacology
Skin - drug effects
Skin - metabolism
Skin Absorption - drug effects
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Summary:Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09392b