Ratiometric Fluorescent Probes for the Detection of Reactive Oxygen Species

Reactive oxygen species (ROS) are endogenously produced oxidants with various functions ranging from host defense to signaling. These transient species can cause severe damage to the body when their production is dysregulated or when environmental factors elevate their concentrations. To study their...

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Bibliographic Details
Published in:Chemistry : a European journal 2017-10, Vol.23 (55), p.13549-13573
Main Authors: Andina, Diana, Leroux, Jean‐Christophe, Luciani, Paola
Format: Article
Language:English
Subjects:
Chemistry
Environmental factors
Environmental monitoring
Fluorescence
Fluorescent indicators
fluorescent probes
Oxidants
Oxidizing agents
Probes
ratiometric
reactive oxygen species
sensors
Species
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Summary:Reactive oxygen species (ROS) are endogenously produced oxidants with various functions ranging from host defense to signaling. These transient species can cause severe damage to the body when their production is dysregulated or when environmental factors elevate their concentrations. To study their effects and prevent oxidative harm, tools capable of monitoring ROS in cells and tissue in a sensitive and selective fashion are required. In this Review, a summary of existing ratiometric probes is provided, together with a critical discussion of selected examples. Bright ideas: Reactive oxygen species (ROS) are endogenously produced oxidants with various functions ranging from host defense to signaling. To study their effects and prevent oxidative harm, tools capable of monitoring ROS in cells and tissue in a sensitive and selective fashion are required. In this Review, a summary of existing ratiometric probes is provided, together with a critical discussion of selected examples.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201702458