Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET ac...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-04, Vol.53 (33), p.4569-4572
Main Authors: Kim, Seonghoon, Jo, HyeongChan, Jeon, Mijeong, Choi, Myung-Gyu, Hahn, Sei Kwang, Yun, Seok-Hyun
Format: Article
Language:English
Subjects:
Animals
Bioluminescence
Bioluminescence Resonance Energy Transfer Techniques
Conjugates
Energy transfer
Humans
Illumination
Lesions
Light (illumination)
Luciferases - chemistry
Luciferases - metabolism
Penetration
Photochemotherapy
Renilla - enzymology
Rose Bengal - chemistry
Rose Bengal - metabolism
Singlet oxygen
Singlet Oxygen - metabolism
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Summary:Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc00041c