Iron-core/carbon-shell nanoparticles with intrinsic peroxidase activity: new platform for mimetic glucose detection

Artificial enzymatic mimics based on nanoparticles have become a powerful tool for the improvement of analytical performance in the detection of important bioactive compounds. For the first time the intrinsic peroxidase-like activity of Fe-core/carbon shell nanoparticles (Fe@C NPs) was studied. The...

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Bibliographic Details
Published in:Analytical methods 2017-04, Vol.9 (16), p.2433-2439
Main Authors: Surgutskaya, N. S., Trusova, M. E., Slepchenko, G. B., Minin, A. S., Pershina, A. G., Uimin, M. A., Yermakov, A. E., Postnikov, P. S.
Format: Article
Language:English
Subjects:
Carbon
Catalysis
Catalysts
Glucose
Mathematical analysis
Nanoparticles
Platforms
Surface chemistry
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Summary:Artificial enzymatic mimics based on nanoparticles have become a powerful tool for the improvement of analytical performance in the detection of important bioactive compounds. For the first time the intrinsic peroxidase-like activity of Fe-core/carbon shell nanoparticles (Fe@C NPs) was studied. The catalytic process was described by a typical Michaelis–Menten curve for enzyme kinetics, and the results were comparable with those previously published. The high catalytic performance of the Fe@C NPs allows the development of a new simple procedure for glucose determination with a low detection limit of 0.21 μM. To our knowledge, this is the first study showing the ability to generate active oxygen species on the Fe@C surfaces. We suppose that our investigation will open up a new direction in medicinal applications using these promising materials.
ISSN:1759-9660
1759-9679
DOI:10.1039/C7AY00598A