2,4-Bis(1,1-dimethylethyl)phenol from Cinnamomum loureirii Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the eff...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2017/06/01, Vol.40(6), pp.932-935
Main Authors: Kim, Cho Rong, Choi, Soo Jung, Kim, Jae Kyeom, Park, Chan Kyu, Gim, Min Chul, Kim, Youn-Jung, Park, Gwi Gun, Shin, Dong-Hoon
Format: Article
Language:English
Subjects:
2,4-bis(1,1-dimethylethyl)phenol
Acetylcholinesterase
Acetylcholinesterase - metabolism
acetylcholinesterase inhibitor
Alzheimer’s disease
Animals
Avoidance
Brain
Brain - drug effects
Brain - metabolism
Cinnamomum
Cinnamomum loureirii
Cognition Disorders - chemically induced
Cognition Disorders - drug therapy
Cognition Disorders - metabolism
Cognitive ability
cognitive dysfunction
Learning
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Maze Learning - drug effects
Memory
Memory Disorders - chemically induced
Memory Disorders - drug therapy
Memory Disorders - metabolism
Mice
Mice, Inbred ICR
Neurodegenerative diseases
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Oxidative Stress - drug effects
Peroxidation
Phenols
Phenols - pharmacology
Phenols - therapeutic use
Trimethyltin
Trimethyltin Compounds
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Summary:We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the effects of BP from C. loureirii on learning and memory impairment in trimethyltin (TMT)-treated ICR mice. Y-maze and passive avoidance tests were used to test cognitive ability. Further, changes in biochemical parameters in the brain tissue were also assessed in response to TMT injection and BP intervention. BP pre-administration (20, 40 mg/kg/d) in mice significantly protected cognitive dysfunction induced by TMT (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b16-00997