Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection

We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral van...

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Bibliographic Details
Published in:Clinical infectious diseases 2017-10, Vol.65 (7), p.1214-1217
Main Authors: Patron, Roberto L., Hartmann, Carlos A., Allen, Sorcha, Griesbach, Cheryl L., Kosiorek, Heidi E., Dibaise, John K., Orenstein, Robert
Format: Article
Language:English
Subjects:
Antibiotics
BRIEF REPORTS
Clostridium difficile
Confidence intervals
Failure
Failure analysis
Fecal microflora
Feces
Gram-positive bacteria
Medical procedures
Multivariate analysis
Patients
Recurrent infection
Risk analysis
Risk factors
Transplantation
Vancomycin
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Summary:We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix511