Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection

We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral van...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2017-10, Vol.65 (7), p.1214-1217
Main Authors: Patron, Roberto L., Hartmann, Carlos A., Allen, Sorcha, Griesbach, Cheryl L., Kosiorek, Heidi E., Dibaise, John K., Orenstein, Robert
Format: Article
Language:English
Subjects:
Antibiotics
BRIEF REPORTS
Clostridium difficile
Confidence intervals
Failure
Failure analysis
Fecal microflora
Feces
Gram-positive bacteria
Medical procedures
Multivariate analysis
Patients
Recurrent infection
Risk analysis
Risk factors
Transplantation
Vancomycin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923
cites cdi_FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923
container_end_page 1217
container_issue 7
container_start_page 1214
container_title Clinical infectious diseases
container_volume 65
creator Patron, Roberto L.
Hartmann, Carlos A.
Allen, Sorcha
Griesbach, Cheryl L.
Kosiorek, Heidi E.
Dibaise, John K.
Orenstein, Robert
description We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).
doi_str_mv 10.1093/cid/cix511
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1905733496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26375726</jstor_id><sourcerecordid>26375726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923</originalsourceid><addsrcrecordid>eNpdkc1rFTEUxYMotrZuulcC3YgwNR-TSWYpj1YLLZXyqsshk7lD85xJnkkG2rX_eG99rYKLJCfJ7x6Sewg54uyEs1Z-cn7Acac4f0H2uZK6alTLX6JmylS1kWaPvMl5wxjnhqnXZE8YpZUQbJ_8_m6Di_O984Gu7RYStWGg1z7_pHGkZ9ZPS4I_Epyd6KV3KfY-FkvXyYa8nWwotvgYKBp8QwWhZPrDl1t6DW5JCfd0NcVckh_8MtPBj6N3fgJ6HkZwj6WH5NVopwxvn9YDcnN2ul59rS6uvpyvPl9UTmpZqn4YXNtz2WtdN8I0HKThorZG9bx1o1PWWDFwaGWNbbEtAGirVeMa0Hgg5AH5sPPdpvhrgVy62WcHE_4B4pI73jKlpazbBtHj_9BNXFLA1yGl6lrUQjOkPu4obErOCcZum_xs033HWfcYTYfRdLtoEH7_ZLn0Mwx_0ecsEHi3Aza5xPTvvpFaaZwfALOclRo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1954424270</pqid></control><display><type>article</type><title>Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Oxford Journals Online</source><creator>Patron, Roberto L. ; Hartmann, Carlos A. ; Allen, Sorcha ; Griesbach, Cheryl L. ; Kosiorek, Heidi E. ; Dibaise, John K. ; Orenstein, Robert</creator><creatorcontrib>Patron, Roberto L. ; Hartmann, Carlos A. ; Allen, Sorcha ; Griesbach, Cheryl L. ; Kosiorek, Heidi E. ; Dibaise, John K. ; Orenstein, Robert</creatorcontrib><description>We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/cix511</identifier><identifier>PMID: 28575220</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Antibiotics ; BRIEF REPORTS ; Clostridium difficile ; Confidence intervals ; Failure ; Failure analysis ; Fecal microflora ; Feces ; Gram-positive bacteria ; Medical procedures ; Multivariate analysis ; Patients ; Recurrent infection ; Risk analysis ; Risk factors ; Transplantation ; Vancomycin</subject><ispartof>Clinical infectious diseases, 2017-10, Vol.65 (7), p.1214-1217</ispartof><rights>Copyright © 2017 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>Copyright Oxford University Press, UK Oct 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923</citedby><cites>FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26375726$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26375726$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,58237,58470</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patron, Roberto L.</creatorcontrib><creatorcontrib>Hartmann, Carlos A.</creatorcontrib><creatorcontrib>Allen, Sorcha</creatorcontrib><creatorcontrib>Griesbach, Cheryl L.</creatorcontrib><creatorcontrib>Kosiorek, Heidi E.</creatorcontrib><creatorcontrib>Dibaise, John K.</creatorcontrib><creatorcontrib>Orenstein, Robert</creatorcontrib><title>Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).</description><subject>Antibiotics</subject><subject>BRIEF REPORTS</subject><subject>Clostridium difficile</subject><subject>Confidence intervals</subject><subject>Failure</subject><subject>Failure analysis</subject><subject>Fecal microflora</subject><subject>Feces</subject><subject>Gram-positive bacteria</subject><subject>Medical procedures</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Recurrent infection</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Transplantation</subject><subject>Vancomycin</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpdkc1rFTEUxYMotrZuulcC3YgwNR-TSWYpj1YLLZXyqsshk7lD85xJnkkG2rX_eG99rYKLJCfJ7x6Sewg54uyEs1Z-cn7Acac4f0H2uZK6alTLX6JmylS1kWaPvMl5wxjnhqnXZE8YpZUQbJ_8_m6Di_O984Gu7RYStWGg1z7_pHGkZ9ZPS4I_Epyd6KV3KfY-FkvXyYa8nWwotvgYKBp8QwWhZPrDl1t6DW5JCfd0NcVckh_8MtPBj6N3fgJ6HkZwj6WH5NVopwxvn9YDcnN2ul59rS6uvpyvPl9UTmpZqn4YXNtz2WtdN8I0HKThorZG9bx1o1PWWDFwaGWNbbEtAGirVeMa0Hgg5AH5sPPdpvhrgVy62WcHE_4B4pI73jKlpazbBtHj_9BNXFLA1yGl6lrUQjOkPu4obErOCcZum_xs033HWfcYTYfRdLtoEH7_ZLn0Mwx_0ecsEHi3Aza5xPTvvpFaaZwfALOclRo</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Patron, Roberto L.</creator><creator>Hartmann, Carlos A.</creator><creator>Allen, Sorcha</creator><creator>Griesbach, Cheryl L.</creator><creator>Kosiorek, Heidi E.</creator><creator>Dibaise, John K.</creator><creator>Orenstein, Robert</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection</title><author>Patron, Roberto L. ; Hartmann, Carlos A. ; Allen, Sorcha ; Griesbach, Cheryl L. ; Kosiorek, Heidi E. ; Dibaise, John K. ; Orenstein, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antibiotics</topic><topic>BRIEF REPORTS</topic><topic>Clostridium difficile</topic><topic>Confidence intervals</topic><topic>Failure</topic><topic>Failure analysis</topic><topic>Fecal microflora</topic><topic>Feces</topic><topic>Gram-positive bacteria</topic><topic>Medical procedures</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Recurrent infection</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Transplantation</topic><topic>Vancomycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patron, Roberto L.</creatorcontrib><creatorcontrib>Hartmann, Carlos A.</creatorcontrib><creatorcontrib>Allen, Sorcha</creatorcontrib><creatorcontrib>Griesbach, Cheryl L.</creatorcontrib><creatorcontrib>Kosiorek, Heidi E.</creatorcontrib><creatorcontrib>Dibaise, John K.</creatorcontrib><creatorcontrib>Orenstein, Robert</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patron, Roberto L.</au><au>Hartmann, Carlos A.</au><au>Allen, Sorcha</au><au>Griesbach, Cheryl L.</au><au>Kosiorek, Heidi E.</au><au>Dibaise, John K.</au><au>Orenstein, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>65</volume><issue>7</issue><spage>1214</spage><epage>1217</epage><pages>1214-1217</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>We retrospectively analyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal microbiota transplantation (FMT) at a tertiary referral center between 2011 and 2014 to determine risk factors for FMT failure. In a multivariate analysis, failure to use an oral vancomycin taper preceding FMT was associated with a significant risk of FMT failure (odds ratio, 0.15; 95% confidence interval, .007-.40).</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>28575220</pmid><doi>10.1093/cid/cix511</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1058-4838
ispartof Clinical infectious diseases, 2017-10, Vol.65 (7), p.1214-1217
issn 1058-4838
1537-6591
language eng
recordid cdi_proquest_miscellaneous_1905733496
source JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online
subjects Antibiotics
BRIEF REPORTS
Clostridium difficile
Confidence intervals
Failure
Failure analysis
Fecal microflora
Feces
Gram-positive bacteria
Medical procedures
Multivariate analysis
Patients
Recurrent infection
Risk analysis
Risk factors
Transplantation
Vancomycin
title Vancomycin Taper and Risk of Failure of Fecal Microbiota Transplantation in Patients With Recurrent Clostridium difficile Infection
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T15%3A58%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vancomycin%20Taper%20and%20Risk%20of%20Failure%20of%20Fecal%20Microbiota%20Transplantation%20in%20Patients%20With%20Recurrent%20Clostridium%20difficile%20Infection&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Patron,%20Roberto%20L.&rft.date=2017-10-01&rft.volume=65&rft.issue=7&rft.spage=1214&rft.epage=1217&rft.pages=1214-1217&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/cid/cix511&rft_dat=%3Cjstor_proqu%3E26375726%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-bddc9b13b77462861e38124a85b19cfc5a8a2d1e934109a9eee7a756c6e710923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1954424270&rft_id=info:pmid/28575220&rft_jstor_id=26375726&rfr_iscdi=true