Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death

We studied association of single-nucleotide SCN5A ( rs1805124 ), GJA5 ( rs35594137 ), and KCNN3 ( rs13376333 ) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes ( N =379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup diff...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-05, Vol.163 (1), p.73-77
Main Authors: Ivanova, A. A., Maksimov, V. N., Ivanoshchuk, D. E., Orlov, P. S., Novoselov, V. P., Savchenko, S. V., Voevoda, M. I.
Format: Article
Language:English
Subjects:
Adult
Alleles
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Connexins - genetics
Death
Death, Sudden, Cardiac
Defibrillators
Female
Gap Junction alpha-5 Protein
Gene Frequency - genetics
Gene polymorphism
Genes
Genetic aspects
Genetic Predisposition to Disease - genetics
Genetic research
Genetics
Genotype
Genotype & phenotype
Heart
Heart diseases
Humans
Internal Medicine
Laboratory Medicine
Lifesaving
Male
Middle Aged
NAV1.5 Voltage-Gated Sodium Channel - genetics
Pathology
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphisms
Small-Conductance Calcium-Activated Potassium Channels - genetics
Sudden cardiac death
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Summary:We studied association of single-nucleotide SCN5A ( rs1805124 ), GJA5 ( rs35594137 ), and KCNN3 ( rs13376333 ) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes ( N =379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles . In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p =0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p =0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p =0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3741-y