Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effe...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-05, Vol.163 (1), p.18-21
Main Authors: Zyuz’kov, G. N., Suslov, N. I., Povet’eva, T. N., Nesterova, Yu. V., Afanas’eva, O. G., Udut, E. V., Miroshnichenko, L. A., Simanina, E. V., Polyakova, T. Yu, Stavrova, L. A., Chaikovskii, A. V., Kul’pin, P. V., Udut, V. V., Dygai, A. M., Zhdanov, V. V.
Format: Article
Language:English
Subjects:
Analysis
Animals
Anthracenes - pharmacology
Anthracenes - therapeutic use
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - metabolism
Brain Diseases - drug therapy
Brain Diseases - psychology
Cell Biology
Encephalopathy
Exploratory behavior
Exploratory Behavior - drug effects
General Pathology and Pathophysiology
Internal Medicine
JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases - metabolism
JNK protein
Laboratory Medicine
Male
Mice
Neural stem cells
Neural Stem Cells - drug effects
Pathology
Regenerative Medicine
Stem cells
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Summary:Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3727-9