Differential expression of transcription factors NF-κB and STAT3 in periodontal ligament fibroblasts and gingiva of healthy and diseased individuals

Highlights • Higher activation of NF-κB and STAT3 in diseased than healthy gingiva • Higher activation of NF-κB and STAT3 in PDLF from diseased than healthy tissue • Differential expression of NF-κB and STAT3 in diseased PDLF upon LPS challenge

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Bibliographic Details
Published in:Archives of oral biology 2017-10, Vol.82, p.19-26
Main Authors: Ambili, R, Janam, Prasanthila, Babu, P.S. Saneesh, Prasad, Manu, Vinod, D, Kumar, P.R. Anil, Kumary, T.V, Nair, S. Asha
Format: Article
Language:English
Subjects:
Adult
Advanced Basic Science
Cell biology
Dentistry
Female
Fibroblast
Fibroblasts - metabolism
Gingiva - metabolism
Humans
Immunohistochemistry
Lipopolysaccharides - pharmacology
Male
Microscopy, Confocal
Middle Aged
NF-kappa B
NF-kappa B - metabolism
Periodontal disease
Periodontal Diseases - metabolism
Periodontal Ligament - cytology
Real-Time Polymerase Chain Reaction
RNA, Messenger - metabolism
STAT-3
STAT3 Transcription Factor - metabolism
Transcription factor
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Description
Summary:Highlights • Higher activation of NF-κB and STAT3 in diseased than healthy gingiva • Higher activation of NF-κB and STAT3 in PDLF from diseased than healthy tissue • Differential expression of NF-κB and STAT3 in diseased PDLF upon LPS challenge
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2017.05.010