In-vitro activity of several antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA) isolates expressing aminoglycoside-modifying enzymes: potency of plazomicin alone and in combination with other agents

Highlights • High in-vitro activity of plazomicin against methicillin-resistant Staphylococcus aureus resistant to other aminoglycosides. • The most prevalent aminoglycoside-modifying enzyme (AME) gene was aac(6″)Ie-aph(2′)Ia (87.3%). • Plazomicin activity was not affected by the AMEs detected. • Sy...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2017-08, Vol.50 (2), p.191-196
Main Authors: López Díaz, María Carmen, Ríos, Esther, Rodríguez-Avial, Iciar, Simaluiza, Rosa Janneth, Picazo, Juan José, Culebras, Esther
Format: Article
Language:English
Subjects:
Aminoglycoside-modifying enzymes
Aminoglycosides - metabolism
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacology
Drug Synergism
Humans
Inactivation, Metabolic
Infectious Disease
Methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - enzymology
Microbial Sensitivity Tests
Microbial Viability - drug effects
Plazomicin
Sisomicin - analogs & derivatives
Sisomicin - metabolism
Sisomicin - pharmacology
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Summary:Highlights • High in-vitro activity of plazomicin against methicillin-resistant Staphylococcus aureus resistant to other aminoglycosides. • The most prevalent aminoglycoside-modifying enzyme (AME) gene was aac(6″)Ie-aph(2′)Ia (87.3%). • Plazomicin activity was not affected by the AMEs detected. • Synergy of plazomicin with meropenem was consistently observed against MRSA.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2017.01.039