AOT reverse micelles as versatile reaction media for chitosan nanoparticles synthesis

AOT Reverse Micelles can be used as versatile and controlled reaction media to synthesis of monodisperse Chitosan nanoparticles. [Display omitted] •Ch-NPs were successfully prepared inside n-heptane/AOT/water RMs.•Highly monodisperse NPs were synthesized as confirmed by DLS and SEM techniques.•Ch-NP...

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Bibliographic Details
Published in:Carbohydrate polymers 2017-09, Vol.171, p.85-93
Main Authors: Orellano, M. Soledad, Porporatto, Carina, Silber, Juana J., Falcone, R. Darío, Correa, N. Mariano
Format: Article
Language:English
Subjects:
AOT
Chitosan
Chitosan - chemical synthesis
Chitosan - chemistry
Glutaraldehyde
Micelles
Microscopy, Electron, Scanning
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Reverse micelles
Water - chemistry
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Summary:AOT Reverse Micelles can be used as versatile and controlled reaction media to synthesis of monodisperse Chitosan nanoparticles. [Display omitted] •Ch-NPs were successfully prepared inside n-heptane/AOT/water RMs.•Highly monodisperse NPs were synthesized as confirmed by DLS and SEM techniques.•Ch-NPs can be effectively dispersed in water at physiological pH.•The particle size was mainly dependent on the amount of water of the AOT RMs.•The cross linking reaction inside AOT RMs is more manageable than in bulk water. It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented. Highly monodisperse NPs were synthesized as confirmed by Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) techniques. The particle size was dependent on the reactants concentration, cross-linking degree and mainly the amount of water inside of the AOT RMs used as nanoreactors. While the cross-linking is quite difficult to control in bulk water, the reaction inside the RMs is more manageable and efficient.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2017.04.074