Psychophysical assessment of koniocellular pathway in patients with schizophrenia versus healthy controls

Abstract This study was designed to perform psychophysical assessment of koniocellular pathway in patients with schizophrenia versus healthy controls. A total of 26 patients diagnosed with schizophrenia and 15 healthy controls were included. Snellen Visual Acuity Chart scores and Short Wavelength Au...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2017-08, Vol.266, p.27-34
Main Authors: Timucin, Ozgur Bulent, Aktan Mutlu, Elif, Timucin, Damla, Aslanci, Mehmet Emin, Isıkligil, Isil, Karadag, Mehmet Fatih, Ozbay, Esra Kizildag
Format: Article
Language:English
Subjects:
Adult
Female
Geniculate Bodies - physiopathology
Humans
Koniocellular pathway
Lateral geniculate nucleus
Male
Middle Aged
Psychiatry
Psychophysics
Radiology
Reproducibility of Results
Schizophrenia
Schizophrenia - physiopathology
Sensory Thresholds - physiology
Visual field
Visual Field Tests - standards
Visual Fields - physiology
Visual Pathways - physiopathology
Visual Perception - physiology
Visual processing
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Summary:Abstract This study was designed to perform psychophysical assessment of koniocellular pathway in patients with schizophrenia versus healthy controls. A total of 26 patients diagnosed with schizophrenia and 15 healthy controls were included. Snellen Visual Acuity Chart scores and Short Wavelength Automated Perimetry (SWAP) visual field testing including global visual field indices [mean deviation (MD), pattern standard deviation (PSD), test time (min)], reliability parameters [false negative responses (%), false positive responses (%) and fixed losses (%)] and average threshold sensitivity [central (parafovea), peripheral area, and four quadrants] were recorded in both groups. Significantly lower MD scores, higher PSD scores and lower average threshold sensitivity at each location across the visual field were noted in schizophrenia relative to control group. In conclusion, our findings revealed a deficit in koniocellular pathway with impaired SWAP global indices and lower threshold sensitivity at each location across the visual field among chronic schizophrenic patients as compared with control subjects. Our findings emphasize potential application of SWAP outside its original intended purpose as a glaucoma test, to provide deeper understanding of the specific contribution of lateral geniculate nucleus to the visual and cognitive disturbances of schizophrenia.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2017.05.013