Question 2 Is levosimendan better than milrinone in preventing post operative low cardiac output syndrome and improving cardiac function in children with congenital heart disease?

Structured clinical question In postoperative congenital heart disease children (population), is levosimendan (intervention) better than milrinone (comparison) in improving cardiac function and prevention of LCOS (outcome), shown by heart rate, cardiac output/stroke volume, lactate clearance, inotro...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-06, Vol.102 (6), p.590-592
Main Author: Udayasankar, Sridhurga
Format: Article
Language:English
Subjects:
Accident Prevention
Blood pressure
Cardiac arrhythmia
Cardiovascular diseases
Congenital diseases
Electrocardiography
Heart Disorders
Heart rate
Information Seeking
Mortality
Neonates
Oxygen consumption
Patients
Search Strategies
Statistical Analysis
Surgery
Variance analysis
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Summary:Structured clinical question In postoperative congenital heart disease children (population), is levosimendan (intervention) better than milrinone (comparison) in improving cardiac function and prevention of LCOS (outcome), shown by heart rate, cardiac output/stroke volume, lactate clearance, inotrope requirement, markers of cardiac damage (troponin) and myocardial oxygen consumption (pressure rate index) Search strategy A literature search was performed using The Cochrane Library, Pubmed and Medline using key words 'levosimendan and milrinone' 'pediatric cardiac surgery', which yielded 10 studies and further web search was done, which yielded 18 more relevant studies. No significant difference Power analysis was based on lactate Cardiac output parameters not measured Troponin Troponin at 1 hour 20.7 (15.3-48.3)ng/mL (L) 34.6 (23.8-64.5)ng/mL (M) Heart rate, mean arterial pressure Rate pressure index lower in L (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2017-312660