Pharmacodynamics and effectiveness of topical nitroglycerin at lowering blood pressure during autonomic dysreflexia

Study design: Secondary analysis of prospectively collected observational data assessing the safety of an autonomic dysreflexia (AD) management protocol. Objectives: To estimate the time to onset of action, time to full clinical effect (sustained systolic blood pressure (SBP)

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Bibliographic Details
Published in:Spinal cord 2017-10, Vol.55 (10), p.911-914
Main Authors: Solinsky, R, Bunnell, A E, Linsenmeyer, T A, Svircev, J N, Engle, A, Burns, S P
Format: Article
Language:English
Subjects:
692/308/153
692/308/575
Administration, Topical
Adult
Aged
Aged, 80 and over
Anatomy
Antihypertensives
Autonomic Dysreflexia - drug therapy
Autonomic Dysreflexia - physiopathology
Biomedical and Life Sciences
Biomedicine
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Colon
Confidence intervals
Hospitalization
Human Physiology
Humans
Hypotension
Injuries
Logistic Models
Male
Mathematical models
Middle Aged
Multivariate Analysis
Neurochemistry
Neuropsychology
Neurosciences
Nitroglycerin
Nitroglycerin - administration & dosage
Nitroglycerin - adverse effects
Nitroglycerin - pharmacokinetics
Odds Ratio
Ointments
original-article
Patients
Pharmacodynamics
Pharmacology
Prospective Studies
Regression analysis
Regression models
Retrospective Studies
Secondary analysis
Spinal cord
Spinal cord injuries
Statistical analysis
Treatment Outcome
Vasodilator Agents - administration & dosage
Vasodilator Agents - adverse effects
Vasodilator Agents - pharmacokinetics
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Description
Summary:Study design: Secondary analysis of prospectively collected observational data assessing the safety of an autonomic dysreflexia (AD) management protocol. Objectives: To estimate the time to onset of action, time to full clinical effect (sustained systolic blood pressure (SBP)
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2017.58