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Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients
Objective Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL‐18 in depressive patients. The correlations between these three cytokine concentrations and the patients...
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| Published in: | Human psychopharmacology 2017-07, Vol.32 (4), p.e2588-n/a |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3218-ec34c0cd9bc1177657fe4c7a9bcd808e8025a7d039badd8a40f08a1bdb01c713 |
| container_end_page | n/a |
| container_issue | 4 |
| container_start_page | e2588 |
| container_title | Human psychopharmacology |
| container_volume | 32 |
| creator | Fan, Ni Luo, Yayan Ou, Yufen He, Hongbo |
| description | Objective
Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL‐18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.
Methods
Serum TNF‐α, IL‐6, and IL‐18 concentrations were assessed using enzyme‐linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale‐17.
Results
Depressive patients had increased serum TNF‐α and IL‐6 concentrations but decreased IL‐18 concentrations than controls. TNF‐α and IL‐6 concentrations were significantly positively associated with Hamilton Depression Scale‐17 scores in depressive patients.
Conclusion
These findings provided additional evidence that altered TNF‐α, IL‐6, and IL‐18 activities may contribute to the pathophysiology of depressive disorder. |
| doi_str_mv | 10.1002/hup.2588 |
| format | article |
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Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL‐18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.
Methods
Serum TNF‐α, IL‐6, and IL‐18 concentrations were assessed using enzyme‐linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale‐17.
Results
Depressive patients had increased serum TNF‐α and IL‐6 concentrations but decreased IL‐18 concentrations than controls. TNF‐α and IL‐6 concentrations were significantly positively associated with Hamilton Depression Scale‐17 scores in depressive patients.
Conclusion
These findings provided additional evidence that altered TNF‐α, IL‐6, and IL‐18 activities may contribute to the pathophysiology of depressive disorder.</description><identifier>ISSN: 0885-6222</identifier><identifier>EISSN: 1099-1077</identifier><identifier>DOI: 10.1002/hup.2588</identifier><identifier>PMID: 28582802</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Biomarkers - blood ; cytokines ; depressive disorder ; Depressive Disorder - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; IL‐6 ; Interleukin-18 - blood ; Interleukin-6 - blood ; Linear Models ; lL‐18 ; Male ; Psychiatric Status Rating Scales ; TNF‐α ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Human psychopharmacology, 2017-07, Vol.32 (4), p.e2588-n/a</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3218-ec34c0cd9bc1177657fe4c7a9bcd808e8025a7d039badd8a40f08a1bdb01c713</citedby><cites>FETCH-LOGICAL-c3218-ec34c0cd9bc1177657fe4c7a9bcd808e8025a7d039badd8a40f08a1bdb01c713</cites><orcidid>0000-0001-5914-1869</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28582802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Ni</creatorcontrib><creatorcontrib>Luo, Yayan</creatorcontrib><creatorcontrib>Ou, Yufen</creatorcontrib><creatorcontrib>He, Hongbo</creatorcontrib><title>Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients</title><title>Human psychopharmacology</title><addtitle>Hum Psychopharmacol</addtitle><description>Objective
Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL‐18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.
Methods
Serum TNF‐α, IL‐6, and IL‐18 concentrations were assessed using enzyme‐linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale‐17.
Results
Depressive patients had increased serum TNF‐α and IL‐6 concentrations but decreased IL‐18 concentrations than controls. TNF‐α and IL‐6 concentrations were significantly positively associated with Hamilton Depression Scale‐17 scores in depressive patients.
Conclusion
These findings provided additional evidence that altered TNF‐α, IL‐6, and IL‐18 activities may contribute to the pathophysiology of depressive disorder.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>cytokines</subject><subject>depressive disorder</subject><subject>Depressive Disorder - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>IL‐6</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Linear Models</subject><subject>lL‐18</subject><subject>Male</subject><subject>Psychiatric Status Rating Scales</subject><subject>TNF‐α</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0885-6222</issn><issn>1099-1077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQRi0EoqUgcQLkJYumjJ0_Z1khSitVwKJdW449EUFJE-ykqDuOwFW4CIfgJKS0wIrVfKN5-jR6hJwzGDEAfvXY1iMeCnFA-gySxGMQx4ekD0KEXsQ575ET554Auhskx6THRSi4AN4ny3HRoEVDHdq2pAWusXC0yujibvL5-vbxPqSzeReiIVUrs8tM0HxFDdYWncvXSE3uKmvQ0lo1Oa4ad0qOMlU4PNvPAVlMbhbXU29-fzu7Hs897XMmPNR-oEGbJNWMxXEUxhkGOlbdbgQI7D4MVWzAT1JljFABZCAUS00KTMfMH5DLXW1tq-cWXSPL3GksCrXCqnWSJRAFkWAh_KHaVs5ZzGRt81LZjWQgtw5l51BuHXboxb61TUs0v-CPtA7wdsBLXuDm3yI5XT58F34BVRB8_g</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Fan, Ni</creator><creator>Luo, Yayan</creator><creator>Ou, Yufen</creator><creator>He, Hongbo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5914-1869</orcidid></search><sort><creationdate>201707</creationdate><title>Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients</title><author>Fan, Ni ; Luo, Yayan ; Ou, Yufen ; He, Hongbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3218-ec34c0cd9bc1177657fe4c7a9bcd808e8025a7d039badd8a40f08a1bdb01c713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>cytokines</topic><topic>depressive disorder</topic><topic>Depressive Disorder - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>IL‐6</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Linear Models</topic><topic>lL‐18</topic><topic>Male</topic><topic>Psychiatric Status Rating Scales</topic><topic>TNF‐α</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Ni</creatorcontrib><creatorcontrib>Luo, Yayan</creatorcontrib><creatorcontrib>Ou, Yufen</creatorcontrib><creatorcontrib>He, Hongbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Ni</au><au>Luo, Yayan</au><au>Ou, Yufen</au><au>He, Hongbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients</atitle><jtitle>Human psychopharmacology</jtitle><addtitle>Hum Psychopharmacol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>32</volume><issue>4</issue><spage>e2588</spage><epage>n/a</epage><pages>e2588-n/a</pages><issn>0885-6222</issn><eissn>1099-1077</eissn><abstract>Objective
Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL‐18 in depressive patients. The correlations between these three cytokine concentrations and the patients' clinical characteristics were also assessed.
Methods
Serum TNF‐α, IL‐6, and IL‐18 concentrations were assessed using enzyme‐linked immunosorbent assay from 64 depressive patients and 80 healthy control subjects. Depressive symptoms of patients were assessed using Hamilton Depression Scale‐17.
Results
Depressive patients had increased serum TNF‐α and IL‐6 concentrations but decreased IL‐18 concentrations than controls. TNF‐α and IL‐6 concentrations were significantly positively associated with Hamilton Depression Scale‐17 scores in depressive patients.
Conclusion
These findings provided additional evidence that altered TNF‐α, IL‐6, and IL‐18 activities may contribute to the pathophysiology of depressive disorder.</abstract><cop>England</cop><pmid>28582802</pmid><doi>10.1002/hup.2588</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5914-1869</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-6222 |
| ispartof | Human psychopharmacology, 2017-07, Vol.32 (4), p.e2588-n/a |
| issn | 0885-6222 1099-1077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1906468150 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biomarkers - blood cytokines depressive disorder Depressive Disorder - blood Enzyme-Linked Immunosorbent Assay Female Humans IL‐6 Interleukin-18 - blood Interleukin-6 - blood Linear Models lL‐18 Male Psychiatric Status Rating Scales TNF‐α Tumor Necrosis Factor-alpha - blood |
| title | Altered serum levels of TNF‐α, IL‐6, and IL‐18 in depressive disorder patients |
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