Association Studies of Bone Morphogenetic Protein 2 Gene Polymorphisms With Acute Rejection in Kidney Transplantation Recipients

• Published in: Transplantation proceedings 2017-06, Vol.49 (5), p.1012-1017
• Main Authors: Park, M.-S, Kim, S.K, Park, H.J, Seok, H, Kang, S.W, Lee, S.H, Kim, Y.G, Moon, J.Y, Kim, T.H, Kim, Y.H, Chung, J.-H, Jeong, K.H
• Format: Article
• Language: English
• Subjects: Adult; Bone Morphogenetic Protein 2 - genetics; Female; Genetic Predisposition to Disease - genetics; Genotype; Graft Rejection - genetics; Humans; Kidney Transplantation; Male; Middle Aged; Polymorphism, Single Nucleotide; Surgery
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2017.03.019

Abstract Objective Bone morphogenetic proteins (BMP) belong to the transforming growth factor beta superfamily of proteins. This study was performed to evaluate the association of BMP gene polymorphisms with acute renal allograft rejection (AR) and graft dysfunction (GD) in Koreans. Methods Three hundred thirty-one patients who had kidney transplantation procedures were recruited. Transplantation outcomes were determined in terms of AR and GD criteria. We selected six single nucleotide polymorphisms (SNPs): rs1979855 (5′ near gene), rs1049007 (Ser87Ser), rs235767 (intron), rs1005464 (intron), rs235768 (Arg190Ser), and rs3178250 (3; untranslated region). Results Among the six SNPs tested, the rs235767, rs1005464, and rs3178250 SNPs were significantly associated with AR ( P  < .05). The rs1049007 and rs235768 SNPs also showed an association with GD ( P  < .05). Conclusions In conclusion, these results suggest that the BMP2 gene polymorphism may be related to the development of AR and GD in kidney transplant recipients.