Pediatric sinonasal malignancies: A population-based analysis

• Published in: International journal of pediatric otorhinolaryngology 2017-07, Vol.98, p.97-102
• Main Authors: Chung, Sei Y., B.S, Unsal, Aykut A., D.O, Kılıç, Suat, B.A, Baredes, Soly, M.D., F.A.C.S, Liu, James K., M.D., F.A.C.S, Eloy, Jean Anderson, M.D., F.A.C.S
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; Databases, Factual; Female; Humans; Incidence; Infant; Male; Nasal Cavity - pathology; Nose Neoplasms - epidemiology; Nose Neoplasms - mortality; Nose Neoplasms - pathology; Otolaryngology; Pediatric carcinoma; Pediatric malignancies; Pediatrics; Retrospective Studies; Rhabdomyosarcoma; SEER Program; Sinonasal carcinoma; Sinonasal malignancies; Survival; Survival Rate
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2017.04.032

Abstract Introduction Pediatric Sinonasal Malignancies (PedsSNM) are rare and usually associated with a poor prognosis. We aim to investigate the epidemiology, tumor characteristics, and survival of PedsSNM using a population-based database to augment the scant literature on this topic. Methods The Surveillance, Epidemiology, and End Results database was queried for patients ≤18 years diagnosed with PedsSNM between the years of 1973 and 2013. Data on incidence, tumor characteristics, and survival were analyzed. Results In total, 210 patients with PedsSNM were identified. Demographically, 54.3% were female, 72.6% were white, and the mean age was 10.7 years. Overall incidence was 0.036 per 100,000 individuals between the years of 2000 and 2013. The nasal cavity was the most frequent primary site (37.1%) and rhabdomyosarcoma was the most frequent malignancy (50.5%). Five-, 10-, and 20-year disease-specific survival (DSS) rates were 60.2%, 46.1%, and 20.6%, respectively. Grade IV tumors made up the largest group (37.3%), and such tumors exhibited the worst 5-, 10-, and 20-year survival (P