Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery

In minimally invasive surgery, the white-light thoracoscope as a standard imaging tool is facing challenges of the low contrast between important anatomical or pathological regions and surrounding tissues. Recently, the near-infrared (NIR) fluorescence imaging shows superior advantages over the conv...

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Bibliographic Details
Published in:Journal of biomedical optics 2017-06, Vol.22 (6), p.066002-066002
Main Authors: Mao, Yamin, Wang, Kun, He, Kunshan, Ye, Jinzuo, Yang, Fan, Zhou, Jian, Li, Hao, Chen, Xiuyuan, Wang, Jun, Chi, Chongwei, Tian, Jie
Format: Article
Language:English
Subjects:
Animals
Fluorescence
Humans
Indocyanine Green
Lung Neoplasms - surgery
Minimally Invasive Surgical Procedures - instrumentation
Models, Animal
Reproducibility of Results
Swine
Thoracoscopes - standards
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Summary:In minimally invasive surgery, the white-light thoracoscope as a standard imaging tool is facing challenges of the low contrast between important anatomical or pathological regions and surrounding tissues. Recently, the near-infrared (NIR) fluorescence imaging shows superior advantages over the conventional white-light observation, which inspires researchers to develop imaging systems to improve overall outcomes of endoscopic imaging. We developed an NIR and white-light dual-channel thoracoscope system, which achieved high-fluorescent signal acquisition efficiency and the simultaneously optimal visualization of the NIR and color dual-channel signals. The system was designed to have fast and accurate image registration and high signal-to-background ratio by optimizing both software algorithms and optical hardware components for better performance in the NIR spectrum band. The system evaluation demonstrated that the minimally detectable concentration of indocyanine green (ICG) was 0.01  μM, and the spatial resolution was 35  μm. The in vivo feasibility of our system was verified by the preclinical experiments using six porcine models with the intravenous injection of ICG. Furthermore, the system was successfully applied for guiding the minimally invasive segmentectomy in three lung cancer patients, which revealed that our system held great promise for the clinical translation in lung cancer surgeries.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.22.6.066002